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rs887829

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 2 Higher levels of serum bilirubin, associated with lower risk for coronary artery disease
(G;G) 0 common
Make rs887829(A;G)
ReferenceGRCh38 38.1/141
Chromosome2
Position233759924
GeneUGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10
is asnp
is mentioned by
dbSNPrs887829
ebirs887829
HLIrs887829
Exacrs887829
Varsomers887829
Maprs887829
PheGenIrs887829
hapmaprs887829
1000 genomesrs887829
hgdprs887829
ensemblrs887829
gopubmedrs887829
geneviewrs887829
scholarrs887829
googlers887829
pharmgkbrs887829
gwascentralrs887829
openSNPrs887829
23andMers887829
23andMe allrs887829
SNP Nexus

SNPshotrs887829
SNPdbers887829
MSV3drs887829
GWAS Ctlgrs887829
GMAF0.3108
Max Magnitude2
rs887829 is a SNP in the UGT1A1 gene. The minor allele of this SNP has been reported to be associated with higher levels of serum bilirubin, which has an inverse correlation with coronary artery disease.
? (A;A) (A;G) (G;G) 28

[PMID 19238116] Common variants of four bilirubin metabolism genes and their association with serum bilirubin and coronary artery disease in Chinese Han population. This study of 2,000+ patients reports a recessive protective effect against coronary artery disease for the minor allele, with an age-adjusted odds ratio of 0.24 (CI: 0.10-0.60, p=0.0014).

GWAS snp
PMID [PMID 19419973OA-icon.png]
Trait Bilirubin levels
Title Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia
Risk Allele T
P-val 1E-69
Odds Ratio 0.57 [0.50-0.63] SD decrease



[PMID 21309756] Prevalence of clinically relevant UGT1A alleles and haplotypes in African populations


[PMID 22085899OA-icon.png] UGT1A1 is a major locus influencing bilirubin levels in African Americans

GWAS snp
PMID [PMID 21886157OA-icon.png]
Trait
Title Human metabolic individuality in biomedical and pharmaceutical research.
Risk Allele T
P-val 3E-74
Odds Ratio 0.2930 None
GWAS snp
PMID [PMID 22558097OA-icon.png]
Trait
Title A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.
Risk Allele A
P-val 5E-25
Odds Ratio 0.1900 None


[PMID 17424838] [Genetic polymorphisms of MPO, NQO1, GSTP1, UGT1A6 associated with susceptibility of chronic benzene poisoning].


[PMID 18349273] UGT1A1 genetic polymorphisms, endogenous estrogen exposure, soy food intake, and endometrial cancer risk.


[PMID 19267064] [Relationship between genetic polymorphisms of phase I and phase II metabolizing enzymes and DNA damage of workers exposed to vinyl chloride monomer].


[PMID 19414484OA-icon.png] Genome-wide association meta-analysis for total serum bilirubin levels.


[PMID 19482841OA-icon.png] Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis.


GET Evidence
rs887829
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.354545
summary



GWAS snp
PMID [PMID 23281178]
Trait Metabolite levels
Title A genome-wide assessment of variability in human serum metabolism.
Risk Allele T
P-val 9E-25
Odds Ratio NR NR


[PMID 23642732OA-icon.png] Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study


[PMID 23092954OA-icon.png] SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits.

GWAS snp
PMID [PMID 24625756OA-icon.png]
Trait Serum metabolite levels
Title Genetic determinants influencing human serum metabolome among African Americans.
Risk Allele T
P-val 1E-17
Odds Ratio .32 [NR] unit increase
GWAS snp
PMID [PMID 24816252OA-icon.png]
Trait Blood metabolite levels
Title An atlas of genetic influences on human blood metabolites.
Risk Allele T
P-val 3E-168
Odds Ratio .11 [0.11-0.12] unit increase


[PMID 26413716OA-icon.png] A GWAS Study on Liver Function Test Using eMERGE Network Participants


ClinVar
Risk rs887829(A;A)
Alt rs887829(A;A)
Reference rs887829(G;G)
Significance Drug-response
Disease atazanavir response - Other
Variation info
Gene UGT1A5 UGT1A9 UGT1A3 UGT1A6 UGT1A4 UGT1A1 UGT1A10 UGT1A8 UGT1A7
CLNDBN atazanavir response - Other
Reversed 1
HGVS NC_000002.11:g.234668570C>T
CLNSRC PharmGKB Clinical Annotation PharmGKB
CLNACC RCV000211430.1,