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rs891512

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 3 Higher blood pressure than G;G
(A;G) 2.5 Higher blood pressure than G;G
(G;G) 0.1 Lower blood pressure than those with an A allele
ReferenceGRCh38 38.1/141
Chromosome7
Position151011001
GeneNOS3
is asnp
is mentioned by
dbSNPrs891512
ebirs891512
HLIrs891512
Exacrs891512
Varsomers891512
Maprs891512
PheGenIrs891512
hapmaprs891512
1000 genomesrs891512
hgdprs891512
ensemblrs891512
gopubmedrs891512
geneviewrs891512
scholarrs891512
googlers891512
pharmgkbrs891512
gwascentralrs891512
openSNPrs891512
23andMers891512
23andMe allrs891512
SNP Nexus

SNPshotrs891512
SNPdbers891512
MSV3drs891512
GWAS Ctlgrs891512
GMAF0.1244
Max Magnitude3
? (A;A) (A;G) (G;G) 28
rs891512 (also known as G24943A, IVS25+15 [G→A]) is an intronic variant in the NOS3 gene significantly associated with blood pressure.

[PMID 18246059OA-icon.png] The intronic variant, IVS25+15 [G-->A], was significantly associated with blood pressure; GG homozygotes had significantly lower levels of diastolic blood pressure (DBP) (-2.8 mm Hg; P = 0.016) and systolic blood pressure (SBP) (-1.9 mm Hg; P = 0.018) than A-allele carriers.

[PMID 22425436] eNOS polymorphism rs891512 (G24943A) is associated with hypertension in Chilean individuals (p<0.05).

[PMID 17367796OA-icon.png] Two specific SNPs in significant LD with each other (rs891512 and rs1808593) were significantly associated with ABI (ankle-brachial index) in both subsets.

[PMID 17579350] protective haplotype C-T-A (rs2070744-rs1799983-rs891512) was observed (P = 0.01) with a pronounced effect against suicide completion (P = 0.005).


[PMID 17605790OA-icon.png] Lack of association between endothelial nitric oxide synthase (NOS3) gene polymorphisms and suicide attempts.


[PMID 18482449OA-icon.png] Investigating the complex genetic architecture of ankle-brachial index, a measure of peripheral arterial disease, in non-Hispanic whites.


[PMID 19493349OA-icon.png] 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.


[PMID 21577011] NCAM1, TACR1 and NOS genes and temperament: a study on suicide attempters and controls.


[PMID 26505452] Polymorphic variations in manganese superoxide dismutase (MnSOD) and endothelial nitric oxide synthase (eNOS) genes contribute to the development of type 2 diabetes mellitus in the Chinese Han population