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rs892086

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;G) 0
(C;C) 0 normal
(C;T) 0 normal
(G;G) 0
(T;T) 1.5x increased Alzheimer risk in non-ApoE4 carriers
ReferenceGRCh38 38.1/141
Chromosome19
Position10727001
GeneDNM2
is asnp
is mentioned by
dbSNPrs892086
ebirs892086
HLIrs892086
Exacrs892086
Varsomers892086
Maprs892086
PheGenIrs892086
hapmaprs892086
1000 genomesrs892086
hgdprs892086
ensemblrs892086
gopubmedrs892086
geneviewrs892086
scholarrs892086
googlers892086
pharmgkbrs892086
gwascentralrs892086
openSNPrs892086
23andMers892086
23andMe allrs892086
SNP Nexus

SNPshotrs892086
SNPdbers892086
MSV3drs892086
GWAS Ctlgrs892086
GMAF0.4743
Max Magnitude0
? (C;C) (C;T) (T;T) 28
Carriers with late-onset Alzheimer's disease who have rs892086(T;T) genotypes appear to have less DNM2 mRNA in their brains, according to a study of 429 Japanese patients, and among non-ApoE4 carriers, appear to be at increased risk for developing Alzheimer's disease. The odds ratio reported is 1.53 (CI: 1.08-2.17, p=0.015).[PMID 18236001]