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rs894160

From SNPedia

Orientationminus
Stabilizedminus
Make rs894160(A;A)
Make rs894160(A;G)
Make rs894160(G;G)
ReferenceGRCh38 38.1/141
Chromosome15
Position89668592
GenePLIN1
is asnp
is mentioned by
dbSNPrs894160
ebirs894160
HLIrs894160
Exacrs894160
Varsomers894160
Maprs894160
PheGenIrs894160
hapmaprs894160
1000 genomesrs894160
hgdprs894160
ensemblrs894160
gopubmedrs894160
geneviewrs894160
scholarrs894160
googlers894160
pharmgkbrs894160
gwascentralrs894160
openSNPrs894160
23andMers894160
23andMe allrs894160
SNP Nexus

SNPshotrs894160
SNPdbers894160
MSV3drs894160
GWAS Ctlgrs894160
GMAF0.3324
Max Magnitude
? (A;A) (A;G) (G;G) 28
"We studied a population-based sample of Caribbean-origin Hispanics (n = 920, aged 45-74 y) living in the Boston area. Obesity measures (waist and hip circumference, BMI) did not differ between GG subjects and carriers of the A allele (GA and AA). In multivariate linear regression models, we found a significant interaction between complex carbohydrate intake as a continuous variable and PLIN 11482 G > A genotype for waist circumference (P = 0.002). By dichotomizing complex carbohydrate intake, we found significantly different effects across PLIN 11482G > A genotypes. When complex carbohydrate intake was <144 g/d, waist circumference was larger in PLIN 11482G > A carriers (P = 0.024). Conversely, when complex carbohydrate intake was >/=144 g/d, waist and hip circumferences were less in PLIN 11482G > A carriers (P < 0.05). These interactions were not found for simple sugars or total carbohydrates. In subjects with higher complex carbohydrate intake, the minor allele was protective against obesity, whereas in subjects with lower carbohydrate intake, the minor allele was associated with increased obesity." [PMID 18806092OA-icon.png]


[PMID 19399648] Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants

[PMID 16836753OA-icon.png] Study of the impact of perilipin polymorphisms in a French population.

[PMID 18356850OA-icon.png] Common variations in perilipin gene, central obesity, and risk of type 2 diabetes in US women.

[PMID 18812483OA-icon.png] Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents.

[PMID 19375517OA-icon.png] PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.

[PMID 19385027] Relationship between perilipin gene polymorphisms and body weight and body composition during weight loss and weight maintenance.

[PMID 21193293OA-icon.png] Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance.

[PMID 21392418] Preliminary findings on the role of PLIN1 polymorphisms on body composition and energy metabolism response to energy restriction in obese women.


[PMID 23111648] Evaluation of the ENPP1 and PLIN Single Nucleotide Polymorphisms With Type 2 Diabetes in a Taiwanese Population: Evidence for Replication and Gene-Gene Interaction


[PMID 23517113] Association between three genetic variants of the Perilipin Gene (PLIN) and glucose metabolism: results from a replication study among Chinese adults and a meta-analysis