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rs900400

From SNPedia

Orientationplus
Stabilizedplus
Make rs900400(C;C)
Make rs900400(C;T)
Make rs900400(T;T)
ReferenceGRCh38 38.1/141
Chromosome3
Position157080986
GeneLOC339894
is asnp
is mentioned by
dbSNPrs900400
ebirs900400
HLIrs900400
Exacrs900400
Varsomers900400
Maprs900400
PheGenIrs900400
hapmaprs900400
1000 genomesrs900400
hgdprs900400
ensemblrs900400
gopubmedrs900400
geneviewrs900400
scholarrs900400
googlers900400
pharmgkbrs900400
gwascentralrs900400
openSNPrs900400
23andMers900400
23andMe allrs900400
SNP Nexus

SNPshotrs900400
SNPdbers900400
MSV3drs900400
GWAS Ctlgrs900400
GMAF0.3903
Max Magnitude
? (C;C) (C;T) (T;T) 28
GWAS snp
PMID [PMID 20372150OA-icon.png]
Trait Birth weight
Title Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
Risk Allele C
P-val 2E-35
Odds Ratio 0.09 [0.073-0.10] sd decrease

rs10049088, rs1482853, rs17451107 and rs900400 are in strong linkage disequilibrium (r2>0.93) with each other. [PMID 25244357] reports from the study itself and drawing from previous studies and meta-analysis that while rs900400 is strogly associated with birth adiposity (sum of skinfolds), that association doesn't bear over to childhood adiposity or adulthood BMI [PMID 23202124]. This somewhat remarkable because childhood adoposity is known to be associated with adverse metabolic outcomes [PMID 14710101], but according to present studies rs900400 is not responsible for them [PMID 22484627], its effects disappearing by 3 months of age [PMID 23202124].


[PMID 21307140] Variants near CCNL1/LEKR1 and in ADCY5 and Fetal Growth Characteristics in Different Trimesters

OMIM613459
Desc
Variant
Relatedalso
OMIM613460
Desc
Variant
Relatedalso
[PMID 21885063OA-icon.png] Replication of a genome-wide association study of birth weight in preterm neonates.


[PMID 22073261OA-icon.png] The Birth Weight Lowering C-Allele of rs900400 Near LEKR1 and CCNL1 Associates with Elevated Insulin Release following an Oral Glucose Challenge


[PMID 22685556OA-icon.png] The Interplay of Variants Near LEKR and CCNL1 and Social Stress in Relation to Birth Size

GWAS snp
PMID [PMID 23202124OA-icon.png]
Trait Birth weight
Title New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
Risk Allele C
P-val 4E-38
Odds Ratio .07 [0.060-0.084] gram decrease

[PMID 25244357] The chromosome 3q25 locus associated with fetal adiposity is not associated with childhood adiposity