|| common in complete genomics
|?|| (A;A) (A;G) (G;G) ||28|
is a SNP near the brain-derived neurotrophic factor BDNF
In a study of , the rs908867 was associated with antidepressant response, with heterozygote carriers showing a better response than homozygotes.[PMID 17505499]
However, a critique of this study was published [PMID 18781861], indicating that this finding should be viewed as preliminary until more research is conducted for several reasons, to wit, "First, the study included not only major depression but also bipolar disorder patients; second, various antidepressants were used in this study, which could affect patients' responses; third, the frequency of the haplotype associated with treatment response is rare; and fourth, previous studies of the effects of single BDNF polymorphisms on antidepressant action have reported conflicting findings."
[PMID 21188787] Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder
[PMID 19589503] A brain-derived neurotrophic factor haplotype is associated with therapeutic response in obsessive-compulsive disorder.
[PMID 21172166] Pharmacogenetics of antidepressant response.
[PMID 26115627] Single nucleotide polymorphisms in the BDNF gene and suicide in the Slovenian sample