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rs908867

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(G;G) 0 common in complete genomics
Make rs908867(A;A)
Make rs908867(A;G)
ReferenceGRCh38 38.1/141
Chromosome11
Position27724217
is asnp
is mentioned by
dbSNPrs908867
ebirs908867
HLIrs908867
Exacrs908867
Varsomers908867
Maprs908867
PheGenIrs908867
hapmaprs908867
1000 genomesrs908867
hgdprs908867
ensemblrs908867
gopubmedrs908867
geneviewrs908867
scholarrs908867
googlers908867
pharmgkbrs908867
gwascentralrs908867
openSNPrs908867
23andMers908867
23andMe allrs908867
SNP Nexus

SNPshotrs908867
SNPdbers908867
MSV3drs908867
GWAS Ctlgrs908867
GMAF0.07943
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs908867 is a SNP near the brain-derived neurotrophic factor BDNF gene.

In a study of , the rs908867 was associated with antidepressant response, with heterozygote carriers showing a better response than homozygotes.[PMID 17505499]

However, a critique of this study was published [PMID 18781861], indicating that this finding should be viewed as preliminary until more research is conducted for several reasons, to wit, "First, the study included not only major depression but also bipolar disorder patients; second, various antidepressants were used in this study, which could affect patients' responses; third, the frequency of the haplotype associated with treatment response is rare; and fourth, previous studies of the effects of single BDNF polymorphisms on antidepressant action have reported conflicting findings."


[PMID 21188787] Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder

[PMID 19589503] A brain-derived neurotrophic factor haplotype is associated with therapeutic response in obsessive-compulsive disorder.

[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.


[PMID 26115627] Single nucleotide polymorphisms in the BDNF gene and suicide in the Slovenian sample