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rs924607

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common/normal
(C;T) 0 common/normal
(T;T) 1.5 in childhood acute lymphoblastic leukemia patients, worse response to vincristine
ReferenceGRCh38 38.1/142
Chromosome5
Position609978
GeneLOC100996325
is asnp
is mentioned by
dbSNPrs924607
ebirs924607
HLIrs924607
Exacrs924607
Varsomers924607
Maprs924607
PheGenIrs924607
hapmaprs924607
1000 genomesrs924607
hgdprs924607
ensemblrs924607
gopubmedrs924607
geneviewrs924607
scholarrs924607
googlers924607
pharmgkbrs924607
gwascentralrs924607
openSNPrs924607
23andMers924607
23andMe allrs924607
SNP Nexus

SNPshotrs924607
SNPdbers924607
MSV3drs924607
GWAS Ctlgrs924607
Max Magnitude1.5

In a study of ~300 patients with childhood acute lymphoblastic leukemia (ALL) treated with vincristine, rs924607(T;T) patients, 28 of 50 (56%) developed at least 1 episode of grade 2 to 4 peripheral neuropathy. This was a significantly higher rate than in patients with (C;C) or (C;T) genotypes (58/271 patients; p = 2.4×10e-6). The severity of neuropathy was also greater in (T;T) patients.[PMID 25710658OA-icon.png]

? (C;C) (C;T) (T;T) 28


[PMID 27618250] An inherited genetic variant in CEP72 promoter predisposes to vincristine-induced peripheral neuropathy in adults with acute lymphoblastic leukemia.