Have questions? Visit https://www.reddit.com/r/SNPedia

rs925489

From SNPedia

Orientationplus
Stabilizedplus
Make rs925489(C;C)
Make rs925489(C;T)
Make rs925489(T;T)
ReferenceGRCh38 38.1/141
Chromosome9
Position97784318
is asnp
is mentioned by
dbSNPrs925489
ebirs925489
HLIrs925489
Exacrs925489
Varsomers925489
Maprs925489
PheGenIrs925489
hapmaprs925489
1000 genomesrs925489
hgdprs925489
ensemblrs925489
gopubmedrs925489
geneviewrs925489
scholarrs925489
googlers925489
pharmgkbrs925489
gwascentralrs925489
openSNPrs925489
23andMers925489
23andMe allrs925489
SNP Nexus

SNPshotrs925489
SNPdbers925489
MSV3drs925489
GWAS Ctlgrs925489
GMAF0.2254
Max Magnitude
? (C;C) (C;T) (T;T) 28

Highest association to hypothyroidism in 23andMe cohort based [PMID 22493691OA-icon.png], association found also in the first hypothyroidism GWAS [PMID 21981779OA-icon.png]. It is 69kb upstream of the gene FOXE1 Forkhead Box E1 which is also known as TTF-2 Thyroid Transcription Factor 2, whose expression it affects according to the first study. In the more recent study, it had an odds ratio of 0.78 with a p-value of 2.4*10-19, meaning the minor allele C is protective. In the first study the C allele was also found associated with lower Serum thyroid-stimulating hormone levels, and homozygous CC allele potentially associated with Papillary Thyroid Cancer.

[PMID 24852370] Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations.

[PMID 22493691OA-icon.png] Novel associations for hypothyroidism include known autoimmune risk Loci

[PMID 21981779OA-icon.png] Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies.

GWAS snp
PMID [PMID 24852370]
Trait Serum thyroid-stimulating hormone levels
Title Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations.
Risk Allele C
P-val 1E-13
Odds Ratio .06 [NR] unit decrease