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rs925946

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 0 common in complete genomics
Make rs925946(G;T)
Make rs925946(T;T)
ReferenceGRCh38 38.1/141
Chromosome11
Position27645655
GeneBDNF-AS
is asnp
is mentioned by
dbSNPrs925946
ebirs925946
HLIrs925946
Exacrs925946
Varsomers925946
Maprs925946
PheGenIrs925946
hapmaprs925946
1000 genomesrs925946
hgdprs925946
ensemblrs925946
gopubmedrs925946
geneviewrs925946
scholarrs925946
googlers925946
pharmgkbrs925946
gwascentralrs925946
openSNPrs925946
23andMers925946
23andMe allrs925946
SNP Nexus

SNPshotrs925946
SNPdbers925946
MSV3drs925946
GWAS Ctlgrs925946
GMAF0.2282
Max Magnitude0
? (G;G) (G;T) (T;T) 28
GWAS snp
PMID [PMID 19079260]
Trait Body mass index
Title Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
Risk Allele T
P-val 9E-10
Odds Ratio 3.85 [2.62-5.08] % SD



[PMID 21188787] Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder


[PMID 21796141] Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area


[PMID 21912638OA-icon.png] Studies of metabolic phenotypic correlates of 15 obesity associated gene variants


[PMID 19478790OA-icon.png] The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.


[PMID 19526209OA-icon.png] Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?


[PMID 19553259OA-icon.png] Common body mass index-associated variants confer risk of extreme obesity.


[PMID 20520848OA-icon.png] Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth.


[PMID 20712903OA-icon.png] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.


[PMID 20724581OA-icon.png] Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.


[PMID 20824172OA-icon.png] Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.


GET Evidence
rs925946
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.722222
summary



Obesity: Preliminary Research


[PMID 23640704] Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations


[PMID 23318717] Sex-specific effects of weight-affecting gene variants in a life course perspective--The HUNT Study, Norway.


[PMID 26739449] Serum Brain-Derived Neurotrophic Factor is Related to Platelet Reactivity but not to Genetic Polymorphisms within BDNF Encoding Gene in Patients with Type 2 Diabetes.