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rs9277535

From SNPedia

Orientationplus
Stabilizedplus
Make rs9277535(A;A)
Make rs9277535(A;G)
Make rs9277535(G;G)
ReferenceGRCh38 38.1/141
Chromosome6
Position33087084
GeneHLA-DPB1
is asnp
is mentioned by
dbSNPrs9277535
ebirs9277535
HLIrs9277535
Exacrs9277535
Varsomers9277535
Maprs9277535
PheGenIrs9277535
hapmaprs9277535
1000 genomesrs9277535
hgdprs9277535
ensemblrs9277535
gopubmedrs9277535
geneviewrs9277535
scholarrs9277535
googlers9277535
pharmgkbrs9277535
gwascentralrs9277535
openSNPrs9277535
23andMers9277535
23andMe allrs9277535
SNP Nexus

SNPshotrs9277535
SNPdbers9277535
MSV3drs9277535
GWAS Ctlgrs9277535
GMAF0.3264
Max Magnitude
? (A;A) (A;G) (G;G) 28

23andMe blog rs3077(A) and rs9277535(A) may reduce risk of Hepatitis B infection

GWAS snp
PMID [PMID 19349983]
Trait Hepatitis B
Title A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians
Risk Allele G
P-val 6E-39
Odds Ratio



[PMID 21346778OA-icon.png] Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver


[PMID 21750111] A Genome-Wide Association Study of Chronic Hepatitis B Identified Novel Risk Locus in a Japanese Population

GWAS snp
PMID [PMID 21764829]
Trait
Title A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region.
Risk Allele
P-val 3E-12
Odds Ratio 1.3900 [1.23-1.59]


[PMID 21904616OA-icon.png] Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study


[PMID 22543033] Relationship between HLA-DP gene polymorphisms and clearance of chronic hepatitis B virus infections: Case-control study and meta-analysis


[PMID 22448225OA-icon.png] A common HLA-DPA1 variant is associated with hepatitis B virus infection but fails to distinguish active from inactive Caucasian carriers


[PMID 22807686OA-icon.png] GWAS Identifies Novel Susceptibility Loci on 6p21.32 and 21q21.3 for Hepatocellular Carcinoma in Chronic Hepatitis B Virus Carriers


[PMID 19458352OA-icon.png] Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.


[PMID 20436909OA-icon.png] The textile plot: a new linkage disequilibrium display of multiple-single nucleotide polymorphism genotype data.


[PMID 20639879OA-icon.png] Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.


[PMID 21310144] Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment.


[PMID 21408128OA-icon.png] Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies.


[PMID 22105689] Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development.


[PMID 22496224OA-icon.png] A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection.

GWAS snp
PMID [PMID 22737229OA-icon.png]
Trait
Title Genome-Wide Association Study Confirming Association of HLA-DP with Protection against Chronic Hepatitis B and Viral Clearance in Japanese and Korean.
Risk Allele G
P-val 2E-21
Odds Ratio 1.6400 None


GET Evidence
rs9277535
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.274194
summary



[PMID 23326374OA-icon.png] Host genetic factors affecting spontaneous HBsAg seroclearance in chronic hepatitis B patients

GWAS snp
PMID [PMID 23760081]
Trait Chronic hepatitis B infection
Title A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
Risk Allele
P-val 4E-40
Odds Ratio 1.89 [1.72-2.08]


[PMID 23428460] Genetic variants in HLA-DP/DQ contribute to risk of cervical cancer: a two-stage study in Chinese women.


[PMID 23601003] Association of the rs3077 and rs9277535 polymorphisms in HLA-DP with hepatitis B virus infection and spontaneous clearance: a meta-analysis.

GWAS snp
PMID [PMID 24940741OA-icon.png]
Trait Chronic hepatitis B infection
Title A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese.
Risk Allele G
P-val 5E-14
Odds Ratio 1.59 [1.41-1.79]


[PMID 25802187] Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B


[PMID 25449085] [Studies on the association of single nucleotide polymorphisms of HLA-DP and DQ genes with the outcome of chronic hepatitis B virus infection]


[PMID 25376093OA-icon.png] Association between single-nucleotide polymorphisms and early spontaneous hepatitis B virus e antigen seroconversion in children


[PMID 26634522] Relationship between HLA-DP gene polymorphisms and the risk of hepatocellular carcinoma: a meta-analysis.


[PMID 27291710] Association of human leukocyte antigen DP/DQ gene polymorphisms with chronic hepatitis B in Chinese Han and Uygur populations.


[PMID 27394003] Association of HLA-DP/DQ and STAT4 polymorphisms with ankylosing spondylitis in Southwest China.


[PMID 27595289] Novel HLA-DP region susceptibility loci associated with severe acute GvHD.