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rs9282860

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common/normal
(C;T) 1.7 slightly increased risk for multiple sclerosis in females
(T;T) 2 slightly increased risk for multiple sclerosis in females
ReferenceGRCh38 38.1/142
Chromosome19
Position1221162
GeneSTK11
is asnp
is mentioned by
dbSNPrs9282860
ebirs9282860
HLIrs9282860
Exacrs9282860
Varsomers9282860
Maprs9282860
PheGenIrs9282860
hapmaprs9282860
1000 genomesrs9282860
hgdprs9282860
ensemblrs9282860
gopubmedrs9282860
geneviewrs9282860
scholarrs9282860
googlers9282860
pharmgkbrs9282860
gwascentralrs9282860
openSNPrs9282860
23andMers9282860
23andMe allrs9282860
SNP Nexus

SNPshotrs9282860
SNPdbers9282860
MSV3drs9282860
GWAS Ctlgrs9282860
Max Magnitude2

rs9282860 is a SNP within intron 5 of the STK11 gene; the minor allele is carried by about 7% of the population in one study.

Based on sequencing of a family in which five siblings were diagnosed with multiple sclerosis (MS), rs9282860 was then screened in 654 relapsing-remitting MS patients, 100 primary progressive MS patients, and 661 controls. rs9282860(T) was found more frequently in all female patients versus controls (odds ratio 1.66, CI: 1.05-2.64, p = .032). However, it was not associated with disease duration or onset. It was significantly associated with reduced severity, with the lowest MS severity scores in patients who also harbored the HLA-DRB1*1501 allele (tagged by rs3135388 and by itself strongly associated with MS).[PMID 25694554OA-icon.png]