rs9303542

plus

Geno	Mag	Summary
(A;A)	0
(A;G)	1.1	1.1x increased risk for ovarian cancer
(G;G)	1.2	1.2x increased risk for ovarian cancer

Reference

GRCh38 38.1/141

Chromosome

17

Position

48334138

Gene

SKAP1

is a	snp
is	mentioned by
dbSNP	rs9303542
dbSNP (classic)	rs9303542
ClinGen	rs9303542
ebi	rs9303542
HLI	rs9303542
Exac	rs9303542
Gnomad	rs9303542
Varsome	rs9303542
LitVar	rs9303542
Map	rs9303542
PheGenI	rs9303542
Biobank	rs9303542
1000 genomes	rs9303542
hgdp	rs9303542
ensembl	rs9303542
geneview	rs9303542
scholar	rs9303542
google	rs9303542
pharmgkb	rs9303542
gwascentral	rs9303542
openSNP	rs9303542
23andMe	rs9303542
SNPshot	rs9303542
SNPdbe	rs9303542
MSV3d	rs9303542
GWAS Ctlg	rs9303542

GMAF

0.3108

Max Magnitude

1.2

rs9303542 is a SNP on chromosome 17q21, located in the intron of src kinase associated phosphoprotein 1 SKAP1 gene.

A genome-wide association study ultimately including over 10,000 ovarian cancer patients found statistically strong (p = 1.4 × 10e-7) evidence for slightly elevated risk associated with the rs9303542(G) allele, with an odds ratio of 1.14 (CI: 1.09–1.20) as calculated for the serous subtype (of ovarian cancer).[PMID 20852632 ]

?

(A;A) (A;G) (G;G)

28

GWAS snp
PMID	[PMID 20852632 ]
Trait
Title	A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24
Risk Allele	G
P-val	0.000001
Odds Ratio	1.11 [1.06-1.16]

[PMID 22253144 ] Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers.

GWAS snp
PMID	[PMID 23535730 ]
Trait	Ovarian cancer
Title	GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
Risk Allele
P-val	6E-9
Odds Ratio	1.12 [1.08-1.16]

[PMID 25173882 ] Replication Study for the Association of Seven Genome- Gwas-Identified Loci With Susceptibility to Ovarian Cancer in the Polish Population