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rs944289

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0
(C;T) 2.1 1.3x increased thyroid cancer risk
(T;T) 2.2 1.69x increased thyroid cancer risk
ReferenceGRCh38 38.1/141
Chromosome14
Position36180040
is asnp
is mentioned by
dbSNPrs944289
ebirs944289
HLIrs944289
Exacrs944289
Varsomers944289
Maprs944289
PheGenIrs944289
hapmaprs944289
1000 genomesrs944289
hgdprs944289
ensemblrs944289
gopubmedrs944289
geneviewrs944289
scholarrs944289
googlers944289
pharmgkbrs944289
gwascentralrs944289
openSNPrs944289
23andMers944289
23andMe allrs944289
SNP Nexus

SNPshotrs944289
SNPdbers944289
MSV3drs944289
GWAS Ctlgrs944289
GMAF0.4288
Max Magnitude2.2
? (C;C) (C;T) (T;T) 28
[PMID 19198613OA-icon.png] Each A at rs965513 increased the odds of thyroid cancer by 1.75 times. Each T at rs944289 increased the odds of thyroid cancer by 1.37 times.

A genoset, Gs137, has also been created in SNPedia to represent the increased risk reported for carriers of both variants.

See also: 23andMe blog

OMIM188470
DescTHYROID CARCINOMA, FOLLICULAR; FTC
Variant
Relatedalso
OMIM188550
DescTHYROID CARCINOMA, PAPILLARY
Variant
Relatedalso



[PMID 20350937] The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl


[PMID 21730105] The FOXE1 and NKX2-1 loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese population


[PMID 22282540OA-icon.png] Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24


[PMID 22586128OA-icon.png] The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type


[PMID 20628519OA-icon.png] Genetic Predisposition to Familial Nonmedullary Thyroid Cancer: An Update of Molecular Findings and State-of-the-Art Studies.


GET Evidence
rs944289
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.398438
summary



[PMID 23659773OA-icon.png] Cumulative Risk Impact of Five Genetic Variants Associated With Papillary Thyroid Carcinoma


[PMID 23847140] Confirmation of papillary thyroid cancer susceptibility loci identified by genome-wide association studies of chromosomes 14q13, 9q22, 2q35 and 8p12 in a Chinese population


[PMID 24325646OA-icon.png] FOXE1 association with differentiated thyroid cancer and its progression


[PMID 24591304OA-icon.png] Significant SNPs have limited prediction ability for thyroid cancer


[PMID 25849217OA-icon.png] Common Variants at 9q22.33, 14q13.3, and ATM Loci, and Risk of Differentiated Thyroid Cancer in the French Polynesian Population


[PMID 25879635OA-icon.png] Common variants at the 9q22.33, 14q13.3 and ATM loci, and risk of differentiated thyroid cancer in the Cuban population


[PMID 25746573] Clinical significance of papillary thyroid cancer risk loci identified by genome-wide association studies


[PMID 26490305] Association Between GWAS-derived rs966423 Genetic Variant and Overall Mortality in Patients with Differentiated Thyroid Cancer