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rs9469220

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1.5x risk of Crohn's disease
(A;G) 1.1x risk of Crohn's disease
(C;C) 0
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome6
Position32690533
is asnp
is mentioned by
dbSNPrs9469220
ebirs9469220
HLIrs9469220
Exacrs9469220
Varsomers9469220
Maprs9469220
PheGenIrs9469220
hapmaprs9469220
1000 genomesrs9469220
hgdprs9469220
ensemblrs9469220
gopubmedrs9469220
geneviewrs9469220
scholarrs9469220
googlers9469220
pharmgkbrs9469220
gwascentralrs9469220
openSNPrs9469220
23andMers9469220
23andMe allrs9469220
SNP Nexus

SNPshotrs9469220
SNPdbers9469220
MSV3drs9469220
GWAS Ctlgrs9469220
GMAF0.4192
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs9469220 has been reported in a large study to be associated with Crohn's disease.

The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.14 (CI 0.98-1.32), and for homozygotes, 1.52 (CI 1.28-1.79). [PMID 17554300OA-icon.png]

GWAS
SNP rs9469220
PubMedID [PMID 17554300OA-icon.png]
Condition Crohn's disease
Gene NR
Risk Allele A
pValue 2.00E-006
OR 1.14
95% CI 0.98-1.32



[PMID 22615847OA-icon.png] Association Analysis of the Extended MHC Region in Celiac Disease Implicates Multiple Independent Susceptibility Loci


[PMID 17660530] Risk alleles for multiple sclerosis identified by a genomewide study.


[PMID 20369022OA-icon.png] Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.


[PMID 20546594OA-icon.png] An application of Random Forests to a genome-wide association dataset: methodological considerations & new findings.


GET Evidence
rs9469220
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.581967
summary



GWAS snp
PMID [PMID 23146381OA-icon.png]
Trait IgE levels
Title A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.
Risk Allele G
P-val 2E-7
Odds Ratio .09 [0.05-0.12] unit decrease


[PMID 24352087OA-icon.png] Candidate genes involved in beneficial or adverse responses to commonly eaten brassica vegetables in a New Zealand Crohn's disease cohort


[PMID 25308886] Functional relevance for multiple sclerosis-associated genetic variants