Have questions? Visit https://www.reddit.com/r/SNPedia

rs9493857

From SNPedia

Orientationplus
Stabilizedplus
Make rs9493857(A;A)
Make rs9493857(A;G)
Make rs9493857(G;G)
ReferenceGRCh38 38.1/141
Chromosome6
Position134209559
GeneSGK1
is asnp
is mentioned by
dbSNPrs9493857
ebirs9493857
HLIrs9493857
Exacrs9493857
Varsomers9493857
Maprs9493857
PheGenIrs9493857
hapmaprs9493857
1000 genomesrs9493857
hgdprs9493857
ensemblrs9493857
gopubmedrs9493857
geneviewrs9493857
scholarrs9493857
googlers9493857
pharmgkbrs9493857
gwascentralrs9493857
openSNPrs9493857
23andMers9493857
23andMe allrs9493857
SNP Nexus

SNPshotrs9493857
SNPdbers9493857
MSV3drs9493857
GWAS Ctlgrs9493857
GMAF0.3669
Max Magnitude
? (A;A) (A;G) (G;G) 28
10.1371/journal.pgen.1000489 The ancestral allele at rs9493857 results in increased GR-binding and glucocorticoid-regulated gene expression, suggesting that an increased stress response (i.e., glucocorticoid responsiveness) was advantageous in ancestral human populations. We speculate that, in modern times, such variation could favor the negative effects of a heightened glucocorticoid response, potentially predisposing individuals to chronic diseases such as metabolic syndrome and hypertension.

[PMID 19461886OA-icon.png] Adaptive variation regulates the expression of the human SGK1 gene in response to stress