Have questions? Visit https://www.reddit.com/r/SNPedia

rs951266

From SNPedia

Orientationminus
Stabilizedplus
Make rs951266(C;C)
Make rs951266(C;T)
Make rs951266(T;T)
ReferenceGRCh38 38.1/142
Chromosome15
Position78586199
GeneCHRNA5
is asnp
is mentioned by
dbSNPrs951266
ebirs951266
HLIrs951266
Exacrs951266
Varsomers951266
Maprs951266
PheGenIrs951266
hapmaprs951266
1000 genomesrs951266
hgdprs951266
ensemblrs951266
gopubmedrs951266
geneviewrs951266
scholarrs951266
googlers951266
pharmgkbrs951266
gwascentralrs951266
openSNPrs951266
23andMers951266
23andMe allrs951266
SNP Nexus

SNPshotrs951266
SNPdbers951266
MSV3drs951266
GWAS Ctlgrs951266
GMAF0.1892
Max Magnitude
? (C;C) (C;T) (T;T) 28
Rs951266
PubMed [PMID 18385738]
Affy Probeset SNP_A-4302972
Affy Orientation same
On GW 5.0
Alleles A/B C/T
Ancestral C
Population Caucasian(Europe)
Allele T
Case Freq. 0.4
Control Freq. 0.34
Odds Ratio Het
Odds Ratio Hom
Odds Ratio All 1.30
Disease Lung cancer (LC)


rs951266 increases susceptibility to Lung cancer 1.28 times for heterozygotes (CT) and 1.80 times for homozygotes (TT) [PMID 18385676OA-icon.png]

rs951266 increases susceptibility to Lung cancer 1.30 times for carriers of the T allele [PMID 18385738]

rs951266 increases susceptibility to Lung cancer 1.32 times for heterozygotes (CT) and 1.70 times for homozygotes (TT) [PMID 18385739OA-icon.png]

rs951266 increases susceptibility to Peripheral arterial disease 1.21 times for heterozygotes (CT) and 1.41 times for homozygotes (TT) [PMID 18385739OA-icon.png]

rs951266 increases susceptibility to Substance dependence, Nicotine 1.10 times for heterozygotes (CT) and 1.90 times for homozygotes (TT) [PMID 17135278OA-icon.png]

rs951266 increases susceptibility to Substance dependence, Nicotine 1.39 times for heterozygotes (CT) and 1.97 times for homozygotes (TT) [PMID 18385739OA-icon.png]

plos Risk Factors for Age-Dependent Nicotine Addiction

[PMID 17373692OA-icon.png] No evidence for association between 19 cholinergic genes and bipolar disorder.

[PMID 18227835OA-icon.png] Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking.

[PMID 18618000OA-icon.png] A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.

[PMID 18759969OA-icon.png] In search of causal variants: refining disease association signals using cross-population contrasts.

[PMID 19330903OA-icon.png] Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans.

[PMID 19443489OA-icon.png] Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.

[PMID 19706762OA-icon.png] The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

[PMID 20808433OA-icon.png] Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.


[PMID 23196875OA-icon.png] Variants in the 15q25 gene cluster are associated with risk for schizophrenia and bipolar disorder