|| EPCR H1 diplotype; reduced risk of VTE?
|| EPCR H1 haplotype; reduced risk of VTE?
|| normal risk for VTE
|?|| (C;C) (C;G) (G;G) ||28|
is a SNP that can indicate haplotype H1 of the PROCR
gene. The protein product of the PROCR
gene activates a part of the anticoagulation pathway. While the rs9574
(G) allele could indicate haplotypes H2, H3 or H4, the rs9574
(C) allele distinctly tags (identifies) the H1 haplotype.[PMID 17849044
The H1 haplotype (and thus rs9574(C)) has been reported to be associated with a reduced risk of venous thromboembolism (VTE), with an odds ratio of 0.59, CI: 0.41â€“0.84.[PMID 15116250] Two other groups have not found this association to be statistically valid in the populations they studied.[PMID 14576048, PMID 15304035]