Have questions? Visit https://www.reddit.com/r/SNPedia

rs961253

From SNPedia

Orientationplus
Stabilizedplus
Make rs961253(A;A)
Make rs961253(A;C)
Make rs961253(C;C)
ReferenceGRCh38 38.1/141
Chromosome20
Position6423634
is asnp
is mentioned by
dbSNPrs961253
ebirs961253
HLIrs961253
Exacrs961253
Varsomers961253
Maprs961253
PheGenIrs961253
hapmaprs961253
1000 genomesrs961253
hgdprs961253
ensemblrs961253
gopubmedrs961253
geneviewrs961253
scholarrs961253
googlers961253
pharmgkbrs961253
gwascentralrs961253
openSNPrs961253
23andMers961253
23andMe allrs961253
SNP Nexus

SNPshotrs961253
SNPdbers961253
MSV3drs961253
GWAS Ctlgrs961253
GMAF0.2874
Max Magnitude
? (A;A) (A;C) (C;C) 28
nature colorectal cancer rs961253; P = 2.0 times 10-10
GWAS snp
PMID [PMID 19011631OA-icon.png]
Trait Colorectal cancer
Title Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
Risk Allele A
P-val 2E-10
Odds Ratio 1.12 [1.08-1.16]
OMIM612592
DescCOLORECTAL CANCER, SUSCEPTIBILITY TO, 11; CRCS11
Variant
Relatedalso



[PMID 20530476] Risk of Genome-Wide Association Study-Identified Genetic Variants for Colorectal Cancer in a Chinese Population


[PMID 21119214OA-icon.png] Colorectal Cancer Susceptibility Loci in a Population-Based Study: Associations with Morphological Parameters


[PMID 22367214OA-icon.png] Characterization of gene-environment interactions for colorectal cancer susceptibility loci


[PMID 22505654OA-icon.png] GWAS-identified colorectal cancer susceptibility loci associated with clinical outcomes


[PMID 22509336OA-icon.png] The SNP rs961253 in 20p12.3 Is Associated with Colorectal Cancer Risk: A Case-Control Study and a Meta-Analysis of the Published Literature


[PMID 19639606OA-icon.png] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.


[PMID 20501757OA-icon.png] Low-penetrance susceptibility variants in familial colorectal cancer.


[PMID 20648012OA-icon.png] Association studies on 11 published colorectal cancer risk loci.


[PMID 21071539OA-icon.png] Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.


[PMID 21314996OA-icon.png] Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.


[PMID 22045029] Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.


[PMID 22235025] Susceptibility genetic variants associated with early-onset colorectal cancer.


GET Evidence
rs961253
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.328125
summary



[PMID 23359760OA-icon.png] Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population


[PMID 23537995] Evidence of Colorectal Cancer Risk Associated Variant Lys25Ser in the proximity of Human Bone Morphogenetic Protein 2


[PMID 22848671OA-icon.png] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.


[PMID 22999960OA-icon.png] Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.


[PMID 23161572] BMP2/BMP4 colorectal cancer susceptibility loci in northern and southern European populations.


[PMID 23434150OA-icon.png] Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?


[PMID 24875374OA-icon.png] Variation in the Association Between Colorectal Cancer Susceptibility Loci and Colorectal Polyps by Polyp Type