|(G;G)||2||Slightly lower risk of Bladder Cancer.|
|(G;T)||1.5||1.2x increased bladder cancer risk|
|(T;T)||2||1.5x increased bladder cancer risk|
A study ultimately totaling over 4,000 bladder cancer patients of European ancestry (and 40,000 controls) concluded that individuals carrying two copies of rs9642880(T) were at 1.49x increased risk (allele-specific odds ratio = 1.22, p = 9 x 10e-12) for the disease. This SNP was not associated, however, with risk for prostate, breast, or colon cancer.10.1038/ng.229
Another study in Chinese populations found similar results in regard to bladder cancer. [PMID 19369583]
[PMID 18794855] rs9642880(T;T) estimated risk of developing 1.49 times that of noncarriers. 1,803 urinary bladder cancer cases and 34,336 controls. No association with prostate, colorectal and breast cancers.
[PMID 19801959] In contrast to GSTM1 SNPs, the rs9642880(T) was only associated with increased risk for bladder cancer in cases not selected based on exposure to bladder carcinogens such as aromatic amines and polycyclic aromatic hydrocarbons, based on an analysis of 515 bladder cancer cases and 893 controls where the quality and quantity of occupational exposure to bladder carcinogens was documented.
|Condition||Urinary bladder cancer|
|Trait||Urinary bladder cancer|
|Title||A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer|
|Odds Ratio||1.21 [1.15-1.28]|
[PMID 21051319] Risk of Urinary Bladder Cancer is Associated with 8q24 Variant rs9642880[T]: Results from the Los Angeles-Shanghai Case-Control Study
|Title||A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci|
|Odds Ratio||1.2100 [1.16-1.27]|
[PMID 20065031] Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells.
[PMID 22177160] Genetic variability in 8q24 confers susceptibility to urothelial carcinoma of the upper urinary tract and is linked with patterns of disease aggressiveness at diagnosis.
[PMID 23053209] Genetic polymorphisms on 8q24.1 and 4p16.3 are not linked with urothelial carcinoma of the bladder in contrast to their association with aggressive upper urinary tract tumours
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 22994575] Bladder cancer survival in a former industrial area in Saxony-Anhalt, Germany
[PMID 23284801] Distinct SNP combinations confer susceptibility to urinary bladder cancer in smokers and non-smokers
|Title||Genome-wide association study identifies multiple loci associated with bladder cancer risk.|
|Odds Ratio||1.24 [1.20-1.28]|
[PMID 26884936] The association between rs9642880 gene polymorphism and bladder cancer risk: a meta-analysis.