|| 1.5x higher risk for emphysema, higher in smokers
is a SNP in the SERPINE2
A study involving 1,335 consecutive autopsies of elderly Japanese people found emphysema of more than moderate degree in 189 subjects and among 12 examined SNPs, found that only rs975278 was positively associated (with emphysema).rs975278(A;A) individuals were associated with emphysema (odds ratio 1.54, CI: 1.02-2.30, p = 0.037) and the association was more prominent in smokers (odds ratio 2.02, CI: 1.29-3.15, p = 0.002).[PMID 21067581]
|?|| (A;A) (A;G) (G;G) ||28|
[PMID 21611750] Association of SERPINE2 gene with the risk of chronic obstructive pulmonary disease and spirometric phenotypes in northern Han Chinese population
[PMID 22145704] SERPINE2 haplotype as a risk factor for panlobular type of emphysema
[PMID 16358219] The SERPINE2 gene is associated with chronic obstructive pulmonary disease.
[PMID 19017876] Genetic associations with hypoxemia and pulmonary arterial pressure in COPD.
[PMID 19949669] SERPINE2 polymorphisms and chronic obstructive pulmonary disease.
[PMID 20233420] Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation.