|?|| (A;A) (A;G) (G;G) ||28|
has been reported in a large study to be associated with Crohn's disease
The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.09 (CI 0.96-1.24), and for homozygotes, 1.84 (CI 1.49-2.26). [PMID 17554300]
|Desc||INFLAMMATORY BOWEL DISEASE 12; IBD12|
] Variants at the 3p21 locus influence susceptibility and phenotype both in adults and early-onset patients with inflammatory bowel disease
|| [PMID 19915572]
|| Ulcerative colitis
|| Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region
| Risk Allele
| Odds Ratio
|| NR NR
[PMID 19657358] Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility
[PMID 18224312] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
[PMID 18438406] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
[PMID 18533027] Worldwide population differentiation at disease-associated SNPs.
[PMID 18853133] Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
[PMID 19140132] Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.
[PMID 20369022] Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
|| Insufficiently evaluated pathogenic