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rs9886784

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2.5 >3.23 x risk for AD
(A;C) 2.5 3.23x risk for Alzheimer's disease
(C;C) 0 average
ReferenceGRCh37 37.1/131
Chromosome9
Position1521204
is asnp
is mentioned by
dbSNPrs9886784
ebirs9886784
HLIrs9886784
Exacrs9886784
Varsomers9886784
Maprs9886784
PheGenIrs9886784
hapmaprs9886784
1000 genomesrs9886784
hgdprs9886784
ensemblrs9886784
gopubmedrs9886784
geneviewrs9886784
scholarrs9886784
googlers9886784
pharmgkbrs9886784
gwascentralrs9886784
openSNPrs9886784
23andMers9886784
23andMe allrs9886784
SNP Nexus

SNPshotrs9886784
SNPdbers9886784
MSV3drs9886784
GWAS Ctlgrs9886784
GMAF0.2296
Max Magnitude2.5
? (A;A) (A;C) (C;C) 28
rs9886784, a intergenic SNP on chromosome 9, is reported to influence the risk for Alzheimer's disease based on a study of ~1100 Canadian patients. The risk allele is (A); the odds ratio is 3.23 (CI: 1.79 - 5.84). [PMID 17998437]


[PMID 19204163OA-icon.png] GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results. Meta-analysis did NOT show rs9886784 with consistent evidence for association with AD across the investigated data sets:

Genetic association analysis testing of 4 GWA signals (rs7101429 [GAB2], rs7019241 [GOLM1], rs10519262 [chromosome 15q], and rs9886784 [chromosome 9p]) using family-based methods. In the combined analyses, only rs7101429 in GAB2 yielded significant evidence of association with the same allele as in the original GWA study (P =.002). The results are in agreement with recent meta-analyses of this and other GAB2 polymorphisms suggesting approximately a 30% decrease in risk for AD among carriers of the minor alleles. None of the other 3 tested loci showed consistent evidence for association with AD across the investigated data sets.

[PMID 19640594OA-icon.png] Recent insights into the molecular genetics of dementia.