Have questions? Visit https://www.reddit.com/r/SNPedia

SLC16A11

From SNPedia

is agene
is mentioned by
Full namesolute carrier family 16, member 11
EntrezGene162515
PheGenI162515
VariationViewer162515
ClinVarSLC16A11
GeneCardsSLC16A11
dbSNP162515
SADR162515
HugeNav162515
wikipediaSLC16A11
googleSLC16A11
gopubmedSLC16A11
EVSSLC16A11
HEFalMpSLC16A11
MyGene2SLC16A11
23andMeSLC16A11
UniProtQ8NCK7
EnsemblENSG00000174326
# SNPs2
 Max MagnitudeChromosome positionSummary
rs1177678671.57,043,011
rs754935937,041,768


Sequence Variants in SLC16A11 Are a Common Risk Factor for Type 2 Diabetes in Mexico <http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12828.html>

A haplotype of four SNPs in this gene, common in Native Americans, may have originated in Neanderthals.

  • rs117767867 is considered the tag SNP
  • rs13342692
  • rs75418188
  • rs75493593

This haplotype raises the risk by 25% in heterozygotes and 50% in homozygotes for type-2 diabetes, and it may also lead to the development of type-2 diabetes at a younger age and lower BMI. This haplotype is found at ~50% frequency in Native American samples and ~10% in east Asian, but is rare in Europeans and Africans.