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Sulfamethoxazole

From SNPedia

Sulfamethoxazole (SMZ or SMX), is an antibiotic. It was used for bacterial infections such as urinary tract infections, bronchitis, and prostatitis and is effective against both gram negative and positive bacteria. It is now mostly used in combination with trimethoprim (abbreviated SMX-TMP). Other names include: sulfamethalazole, sulfisomezole, and sulfamethazole.Wikipedia

The FDA-approved drug label for sulfamethoxazole contains a precaution for the use of the drug in individuals who are G6PD-deficient due to the risk for hemolysis.

PGx Table for Sulfamethoxazole
Genotype/Genoset Diplotype Gene Drug Use/Category/Class Medical Field Summary Descriptive Sentence
gs309 WT/WT G6PD Anti-bacterial Infectious Disease Normal Response Expected You do not appear to carry any G6PD mutations linked to an unwanted side effect (hemolytic anemia).
gs307 Carrier G6PD Anti-bacterial Infectious Disease Use with Caution You carry a G6PD mutation that might lead to an unwanted side effect (hemolytic anemia) when taking sulfamethoxazole; due to variable expression (i.e. in females), enzymatic testing for G6PD activity is advisable.
gs308 G6PD-deficient G6PD Anti-bacterial Infectious Disease Use with Caution You carry a G6PD mutation potentially linked to an unwanted side effect (hemolytic anemia) when taking sulfamethoxazole; be aware of this possibility.