The PubMed Article from 2012 states that two G alleles offer protection against hypertension on this SNP. This also applies to rs10177833 which is written in the positive, so the letters would be CC instead of GG.
- agreed. fixed. --- cariaso 16:01, 14 July 2015 (UTC)
- The allele designations are correct, but I'm skeptical of the reproducibility of the study cited since so few people were studied, and as far as I could tell, the findings have not been replicated or confirmed since the 2012 publication. [A 2014 review ([PMID 24944762] concluded that "there are still no well-established cause-and-effect relationships for the development of essential hypertension", and they reviewed 129 genes overall, including SLC4A5.] Bottom line: while the conclusion of the 2012 paper is that G alleles may be protective against hypertension, it's a primary report based on a small sample of patients, and since it has not been replicated in larger studies, and the confidence limits around the odds ratios were fairly large anyway, I'm reducing the reported importance/magnitude.Greg (talk) 17:45, 14 July 2015 (UTC)