Tegafur
From SNPedia
Tegafur is a chemotherapeutic prodrug of 5-flourouracil (5-FU) used in the treatment of cancers. It is a component of the combination drug tegafur/uracil. When metabolised, it becomes 5-FU.Wikipedia
As a fluoropyrimidine, several genes (notably the DPYD and TPMT genes) are known to harbor nonfunctional alleles that predispose individuals administered tegafur to potentially severe or even fatal toxicity.
| Genotype/Genoset | Diplotype | Gene | Drug Use/Category/Class | Medical Field | Summary | Descriptive Sentence |
|---|---|---|---|---|---|---|
| gs313 | Normal metabolizer | DPYD | Chemotherapeutic | Oncology | Normal Response Expected | You do not appear to carry any DPYD mutations linked to adverse side effects from tegafur use. |
| gs312 | Intermediate Metabolizer | DPYD | Chemotherapeutic | Oncology | Consider Half-Dose and/or Pharmacokinetic Studies | You carry a nonfunctional DPYD allele that increases your risk for a toxicity upon tegafur administration; consider starting at half-dose and/or doing pharmacokinetic studies. |
| gs306 | Poor Metabolizer | DPYD | Chemotherapeutic | Oncology | Avoid 5-FU; use an alternative drug | You may be at very high risk for severe toxicity from tegafur administration; all major drug regulatory agencies recommend you select a non-fluoropyrimidine alternative chemotherapeutic. |
