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Vitiligo

From SNPedia

Vitiligo is a chronic disorder characterized by loss of pigment in the skin. It appears to be caused by a complex combination of autoimmune, genetic, and environmental factors. Wikipedia

Many SNPs associated with vitiligo are in genes involved with immune system function, such as the major histocompatibility complex (MHC) loci:

  • rs12206499 or rs3823355, the HLA-A*02 MHC Class I allele
  • rs532098 near the HLA-DRB1 gene (each A allele is associated with about 1.6 times higher odds). MHC Class II HLA-DRB1–DQA1 (perhaps HLA-DRB1*04)
  • rs3823355 near the HLA-A gene (each T allele is associated with 1.5 times higher odds)


Other loci:

  • rs1464510 in the LPP gene
  • rs8192917 in the GZMB gene (each C allele is associated with 1.3 times higher odds)
  • rs11203203 in the UBASH3A gene (each A allele is associated with 1.3 times higher odds)
  • rs229527 in the C1QTNF6 gene (each A allele is associated with 1.4 times higher odds)
  • rs2476601 in the PTPN22 gene (each A allele is associated with 1.54 times higher odds)
  • rs231775 in the CTLA4 gene
  • rs2670660 and rs6502867 in the NLRP1 gene
  • rs2269577 in the XBP1 gene
  • rs13208776 in the SMOC2 gene
  • rs1393350 in the TYR gene (the A allele is protective, with each A associated with 0.65 times lower odds)
  • rs4908760 in the RERE gene (each G allele is associated with 1.4 times higher odds)
  • rs13076312 in the LRP gene (each T allele is associated with 1.3 times higher odds)
  • rs706779 in the IL2RA gene (each T allele is associated with 1.3 times higher odds)
  • rs9468925 (the A allele appears to be protective in people of Han Chinese descent; the AA genotype is associated with 0.74 times lower odds than AG, and GG individuals have 1.35 times higher odds)
  • rs2236313 (each T allele is associated with 1.2 times higher odds in a Han Chinese population)