| Geno
|
Mag
|
Summary
|
| (C;C)
|
|
increased risk for Alzheimer's
|
| (C;T)
|
|
increased risk for Alzheimer's
|
| (T;T)
|
0
|
normal risk
|
rs1050283, a SNP also known as +1073, is located in the 3' untranslated region of the oxidized low density lipoprotein (lectin-like) receptor 1 OLR1 gene, which is also known as the LOX-1 gene.
The rs1050283(C) allele has been associated with increased risk for Alzheimer's disease in several studies of ~200 Southern Italian Alzheimer patients. The risk is independent of ApoE status, and may also be defined by haplotypes including one or both of neighboring SNPs rs12316150 and rs669.[PMID 15860461, PMID 18191876]
[PMID 21709374] Role of OLR1 and Its Regulating hsa-miR369-3p in Alzheimer's Disease: Genetics and Expression Analysis
[PMID 18384690
] Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD.
[PMID 20615707] Genetic polymorphisms of Chinese patients with ischemic stroke and concurrent stenoses of extracranial and intracranial vessels.
[PMID 20682755] A pilot study of gene/gene and gene/environment interactions in Alzheimer disease.
[PMID 27840386] Association of the LOX-1 rs1050283 Polymorphism with Risk for Atherosclerotic Cerebral Infarction and its Effect on sLOX-1 and LOX-1 Expression in a Chinese Population.
[PMID 33524863] Association of OLR1 gene polymorphisms with the risk of coronary artery disease: A systematic review and meta-analysis.
] Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD.
