rs2011077

Orientation

minus

Stabilized

minus

Geno	Mag	Summary
(A;A)	1	Normal risk of developing prostate cancer, BPH, and metastatic prostate cancer
(A;G)		In Japanese, 2.4x risk of prostate cancer, 1.7x increased risk of BPH, and 1.5x increased risk of developing metastatic prostate cancer
(G;G)	3	In Japanese, 6.2x increased risk of developing prostate cancer, a 3x increased risk of developing BPH, and a 5.5x increased risk of developing metastatic prostate cancer

Reference

GRCh38 38.1/142

Chromosome

5

Position

177094455

Gene

FGFR4

is a	snp
is	mentioned by
dbSNP	rs2011077
dbSNP (classic)	rs2011077
ClinGen	rs2011077
ebi	rs2011077
HLI	rs2011077
Exac	rs2011077
Gnomad	rs2011077
Varsome	rs2011077
LitVar	rs2011077
Map	rs2011077
PheGenI	rs2011077
Biobank	rs2011077
1000 genomes	rs2011077
hgdp	rs2011077
ensembl	rs2011077
geneview	rs2011077
scholar	rs2011077
google	rs2011077
pharmgkb	rs2011077
gwascentral	rs2011077
openSNP	rs2011077
23andMe	rs2011077
SNPshot	rs2011077
SNPdbe	rs2011077
MSV3d	rs2011077
GWAS Ctlg	rs2011077

GMAF

0.2493

Max Magnitude

3

?	(A;A) (A;G) (G;G)	28

A study of ~500 Japanese prostate cancer patients found that individuals with a rs2011077(G;G) genotype had a 6.2- and 3-fold increased risk of prostate cancer and benign prostate hyperplasia (BPH), and a 5.5-fold increased risk of metastatic prostate cancer, compared to the (A;A) genotype.[PMID 18756523]

[PMID 31878098] Involvement of FGFR4 Gene Variants on the Clinicopathological Severity in Urothelial Cell Carcinoma.