rs2968863

minus

Geno	Mag	Summary
(A;A)	2	Possibly slightly higher (2.4x) risk for atrial fibrillation
(G;G)	0	common/normal

Make rs2968863(A;G)

Reference

GRCh38 38.1/142

Chromosome

7

Position

150926049

is a	snp
is	mentioned by
dbSNP	rs2968863
dbSNP (classic)	rs2968863
ClinGen	rs2968863
ebi	rs2968863
HLI	rs2968863
Exac	rs2968863
Gnomad	rs2968863
Varsome	rs2968863
LitVar	rs2968863
Map	rs2968863
PheGenI	rs2968863
Biobank	rs2968863
1000 genomes	rs2968863
hgdp	rs2968863
ensembl	rs2968863
geneview	rs2968863
scholar	rs2968863
google	rs2968863
pharmgkb	rs2968863
gwascentral	rs2968863
openSNP	rs2968863
23andMe	rs2968863
SNPshot	rs2968863
SNPdbe	rs2968863
MSV3d	rs2968863
GWAS Ctlg	rs2968863

GMAF

0.1345

Max Magnitude

2

A 2013 study of 358 atrial fibrillation patients with early-onset (before the age of 50) reported that rs2968863(A;A) individuals had higher AF risk (OR 2.40, p = 0.001 and p= 0.016 after Bonferroni correction). Heterozygotes were not at increased risk.[PMID 24074973]

As that study stated, the rs2968863 variant had previously been shown in GWAS studies to decrease the QTc interval by 1.4ms.[PMID 19305408 ]

?

(A;A) (A;G) (G;G)

28

GWAS snp
PMID	[PMID 19305409 ]
Trait	QT interval
Title	Common variants at ten loci modulate the QT interval duration in the QTSCD Study
Risk Allele	T
P-val	2E-15
Odds Ratio	1.35 [0.90-1.80] ms decrease

[PMID 32490690 ] Validation and Disease Risk Assessment of Previously Reported Genome-Wide Genetic Variants Associated with Brugada Syndrome: SADS-TW BrS Registry.