rs3761847
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | normal |
| (A;G) | 2.1 | 1.32 x risk of rheumatoid arthritis. |
| (G;G) | 2.2 | >1.32 x risk of rheumatoid arthritis |
| Reference | GRCh38 38.1/141 |
| Chromosome | 9 |
| Position | 120927961 |
| Gene | TRAF1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs3761847 |
| dbSNP (classic) | rs3761847 |
| ClinGen | rs3761847 |
| ebi | rs3761847 |
| HLI | rs3761847 |
| Exac | rs3761847 |
| Gnomad | rs3761847 |
| Varsome | rs3761847 |
| LitVar | rs3761847 |
| Map | rs3761847 |
| PheGenI | rs3761847 |
| Biobank | rs3761847 |
| 1000 genomes | rs3761847 |
| hgdp | rs3761847 |
| ensembl | rs3761847 |
| geneview | rs3761847 |
| scholar | rs3761847 |
| rs3761847 | |
| pharmgkb | rs3761847 |
| gwascentral | rs3761847 |
| openSNP | rs3761847 |
| 23andMe | rs3761847 |
| SNPshot | rs3761847 |
| SNPdbe | rs3761847 |
| MSV3d | rs3761847 |
| GWAS Ctlg | rs3761847 |
| GMAF | 0.4816 |
| Max Magnitude | 2.2 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs3761847, a SNP located between two genes associated with chronic inflammation (TRAF1 and C5), is associated with increased risk of anti CCP-positive rheumatoid arthritis.
The risk allele is (G); the odds ratio reported is 1.32 (95% confidence interval, 1.23 to 1.42; P=4x10-14) [PMID 17804836
].
[PMID 19116907] rs3761847(G;G) associated with an increased risk of death (hazard ratio 3.96 [95% confidence interval 1.24-12.6], P = 0.020) as compared with (A;A) homozygote status. The excess mortality was attributed to deaths due to malignancies and sepsis but not cardiovascular disease (CVD).
| GWAS | |
|---|---|
| SNP | rs3761847 |
| PubMedID | [PMID 17804836]
|
| Condition | Rheumatoid arthritis |
| Gene | TRAF1-C5 |
| Risk Allele | G |
| pValue | 4.00E-014 |
| OR | 1.32 |
| 95% CI | 1.23-1.42 |
[PMID 19401279] Susceptibility variants for rheumatoid arthritis in the TRAF1-C5 and 6q23 loci: a meta-analysis
[PMID 19565500] Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis
[PMID 19714643] TRAF1 polymorphisms associated with rheumatoid arthritis susceptibility in Asians and in Caucasians
[PMID 19336421] Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese
| GWAS snp | |
|---|---|
| PMID | [PMID 20453842]
|
| Trait | Rheumatoid arthritis |
| Title | Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk lock |
| Risk Allele | G |
| P-val | 2E-7 |
| Odds Ratio | 1.13 [1.08-1.18] |
[PMID 18224312] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
[PMID 18434327] Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility.
[PMID 18648537] A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2.
[PMID 18794853] Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
[PMID 18987647] Rheumatoid arthritis: a view of the current genetic landscape.
[PMID 19180477] Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations.
[PMID 19445664] Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls.
[PMID 19674979] Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.
[PMID 19849816] Genetics of rheumatic disease.
[PMID 20017974] Simultaneous analysis of all single-nucleotide polymorphisms in genome-wide association study of rheumatoid arthritis.
[PMID 20017985] Adjusting for HLA-DRbeta1 in a genome-wide association analysis of rheumatoid arthritis and related biomarkers.
[PMID 20017996] Effect of population stratification on the identification of significant single-nucleotide polymorphisms in genome-wide association studies.
[PMID 20018005] Analysis of genome-wide association data by large-scale Bayesian logistic regression.
[PMID 20018006] Case-control genome-wide association study of rheumatoid arthritis from Genetic Analysis Workshop 16 using penalized orthogonal-components regression-linear discriminant analysis.
[PMID 20018022] Replication of recently identified associated single-nucleotide polymorphisms from six autoimmune diseases in Genetic Analysis Workshop 16 rheumatoid arthritis data.
[PMID 20018027] Conditional analysis of the major histocompatibility complex in rheumatoid arthritis.
[PMID 20018028] Armitage's trend test for genome-wide association analysis: one-sided or two-sided?
[PMID 20018035] A combinatorial approach for detecting gene-gene interaction using multiple traits of Genetic Analysis Workshop 16 rheumatoid arthritis data.
[PMID 20018053] A genome-wide association scan for rheumatoid arthritis data by Hotelling's T2 tests.
[PMID 20018062] Identification of genes and haplotypes that predict rheumatoid arthritis using random forests.
[PMID 20018071] Allelic based gene-gene interactions in rheumatoid arthritis.
[PMID 20018074] Identifying rheumatoid arthritis susceptibility genes using high-dimensional methods.
[PMID 20018075] Genome-wide association study of rheumatoid arthritis by a score test based on wavelet transformation.
[PMID 20018090] Comparative analysis of different approaches for dealing with candidate regions in the context of a genome-wide association study.
[PMID 20205706] TRAF1/C5 polymorphism is not associated with increased mortality in rheumatoid arthritis: two large longitudinal studies.
[PMID 20479942] Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.
[PMID 20691091] Survival dimensionality reduction (SDR): development and clinical application of an innovative approach to detect epistasis in presence of right-censored data.
[PMID 22820624] Associations between TNFSF4 and TRAF1-C5 gene polymorphisms and systemic lupus erythematosus: a meta-analysis.
[PMID 25834819] TRAF1/C5 but Not PTPRC Variants Are Potential Predictors of Rheumatoid Arthritis Response to Anti-Tumor Necrosis Factor Therapy
[PMID 31570557] Association of TRAF1/C5 locus polymorphisms with epilepsy and clinical traits in Mexican neurocysticercosis patients.
