rs931127

plus

Geno	Mag	Summary
(A;A)	2.1	2.15x more likely positive lymph node
(A;G)
(G;G)	0	more favorable

Reference

GRCh38 38.1/141

Chromosome

11

Position

65637829

Gene	PCNX3, SIPA1

is a	snp
is	mentioned by
dbSNP	rs931127
dbSNP (classic)	rs931127
ClinGen	rs931127
ebi	rs931127
HLI	rs931127
Exac	rs931127
Gnomad	rs931127
Varsome	rs931127
LitVar	rs931127
Map	rs931127
PheGenI	rs931127
Biobank	rs931127
1000 genomes	rs931127
hgdp	rs931127
ensembl	rs931127
geneview	rs931127
scholar	rs931127
google	rs931127
pharmgkb	rs931127
gwascentral	rs931127
openSNP	rs931127
23andMe	rs931127
SNPshot	rs931127
SNPdbe	rs931127
MSV3d	rs931127
GWAS Ctlg	rs931127

GMAF

0.4564

Max Magnitude

2.1

?

(A;A) (A;G) (G;G)

28

PMID: 16563182 This SNP in can have implications for prognosis in breast cancer.

It is located 313 base pairs upstream of the 5'-untranslated region of SIPA1 and is considered to be within the promoter region of the gene. SIPA1 germline polymorphisms are associated with aggressive disease behavior(lymph node metastasis) in the cohort examined

[PMID 19906411 ] Polymorphisms in MMP9 and SIPA1 are associated with increased risk of nodal metastases in early-stage cervical cancer

[PMID 19089925 ] Genetic variation in SIPA1 in relation to breast cancer risk and survival after breast cancer diagnosis.

[PMID 19264455 ] Linkage analysis of schizophrenia in African-American families.

[PMID 19765277 ] Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility.

[PMID 23661532] Sipa1 promoter polymorphism predicts risk and metastasis of lung cancer in Chinese

[PMID 27504716 ] Genes Interacting with Occupational Exposures to Low Molecular Weight Agents and Irritants on Adult-Onset Asthma in Three European Studies.