Promethease 0.1.82
Rs889312
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs889312 |
| hapmap | rs889312 |
| hgdp | rs889312 |
| ensembl | rs889312 |
| gopubmed | rs889312 |
| scholar | rs889312 |
| rs889312 | |
| pharmgkb | rs889312 |
| hgvbaseg2p | rs889312 |
| medrefsnp | rs889312 |
| 23andMe | rs889312 |
| SNP Nexus |
| Chromosome | 5 |
| Orientation | plus |
| Position | 56067641 |
| Genotype | Effect |
|---|---|
| rs889312(A;A)* | ? |
| rs889312(A;C)* | ? |
| rs889312(C;C)* | ? |
rs889312 is a SNP in the MAP3K1 gene.
rs889312 was one of the four strongest associating SNPs found in a genome-wide association study of over 4,000 breast cancer samples. [PMID 17529967]. From a DeCode user report, it appears that the risk allele is C; this A;A individual reportedly has 0.93x risk of breast cancer. [PMID 17529967]
In a study of 1,267 breast cancer patients, rs889312 heterozygotes and minor allele homozygotes were less likely to be lymph node positive at breast cancer diagnosis (P = 0.044) relative to major allele homozygote carriers. [PMID 17997823]
- rs2981582, rs3803662, and rs889312) showed weak but significant associations with ER-negative disease, the strongest association being for rs3803662 in TNRC9 (1.14 (1.09-1.21))
| ? | (A;A) (A;C) (C;C) |
|---|---|
|
| |
| GWAS | |
|---|---|
| SNP | rs889312 |
| PubMedID | [PMID 17529967] |
| Condition | Breast cancer |
| Gene | MAP3K1 |
| Risk Allele | A |
| pValue | 7.00E-020 |
| OR | 1.13 |
| 95% CI | 1.10-1.16 |
Related to BREAST CANCER
according to omim 114480. See also
Related to MITOGEN-ACTIVATED KINASE KINASE KINASE 1; MAP3K1
according to omim 600982. See also
[PMID 19843670] Association of Breast Cancer Susceptibility Variants with Risk of Pancreatic Cancer
| PharmGKB | PA161925627 |
| Name | |
| Annotation | This variant is significantly associated with risk for breast cancer. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:17529967; PubMed ID:17997823 |
| Drugs | |
| Diseases | Breast Neoplasms |
| Curation Level | Curated |
