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ADIPOQ

From SNPedia
is agene
is mentioned by
Full nameadiponectin, C1Q and collagen domain containing
EntrezGene9370
PheGenI9370
VariationViewer9370
ClinVarADIPOQ
GeneCardsADIPOQ
dbSNP9370
DiseasesADIPOQ
SADR9370
HugeNav9370
wikipediaADIPOQ
googleADIPOQ
gopubmedADIPOQ
EVSADIPOQ
HEFalMpADIPOQ
MyGene2ADIPOQ
23andMeADIPOQ
UniProtQ15848
EnsemblENSG00000181092
OMIM605441
# SNPs32
 Max MagnitudeChromosome positionSummary
rs1063537186,856,286
rs1063538186,856,394
rs1063539186,857,603
rs1219178150186,854,303
rs12495941186,850,391
rs144526209186,854,564
rs1501299186,853,334
rs168611940186,841,636
rs168612050186,843,845
rs16861209186,845,325
rs173005391186,841,671
rs173665680186,852,664
rs173666530186,853,027
rs173667430186,854,300
rs178468660186,852,957
rs182052186,842,993
rs2082940186,856,375
rs22417662186,853,103
rs2241767186,853,407
rs2667292186,841,685
rs3774261186,853,770
rs3774262186,854,025
rs6773957186,855,916
rs74577862186,843,903
rs7627128186,851,010
rs7649121186,850,996
rs822391186,846,014
rs822393186,848,537
rs822394186,848,939
rs822395186,849,018
rs822396186,849,088
rs9882205186,852,609

The ADIPOQ gene on chromosome 3 encodes adiponection (APN), a 30kDa glycoprotein composed of 244 amino acids. Sometimes known in literature as the "guardian angel cytokine", adiponection may play a key role in the pathogenesis of obesity-associated cancers along with other diseases such as cardiovascular disease and type-2 diabetes, and in general, having higher levels of adiponectin are a good thing compared to lower levels.

Polymorphisms in the ADIPOQ gene may influence cancer risk. A 2016 review [PMID 27144066OA-icon.png] of these associations includes: