Atrial fibrillation
Disease | |
---|---|
Name | Atrial fibrillation |
DiseasesDB | |
ICD10 | I48 |
ICD9 | 427.31 |
MedlinePlus | 000184 |
MeshID | D001281 |
Atrial fibrillation (AF), a common type of heart arrhythmia, is a major risk factor for stroke. About 15 percent of all strokes are attributable to atrial fibrillation. Anticoagulants such as Warfarin, as well as beta blockers and calcium channel blockers, may be prescribed to reduce the risk of stroke.
How common is atrial fibrillation? Data from the Framingham Heart Study, which followed over 8,000 Massachusetts residents from 1966-1999, indicate that the average lifetime risk after age 40 was 26% for men and 23% for women, and that the risk remained relatively constant as individuals grew older. [PMID 15313941]
In 2018, a large meta-analysis identified 97 loci significantly associated with atrial fibrillation; some of the genes are shown below.10.1038/s41588-018-0133-9
Various genes have been associated with atrial fibrillation:
- GJA5
- rs10465885, also related to hearing loss [PMID 21076161]
- rs35594137
- Other SNPs associated with atrial fibrillation:
- rs2200733
- rs10033464 (risk allele T)
- rs4776472
- rs958546