A large study ultimately including over 4,000 bladder cancer patients of European ancestry (and 40,000 controls) concluded that SNPs rs9642880 and rs710521 are both significantly associated with increased risk for the disease.10.1038/ng.229
More interestingly, variation in genes involved in DNA repair (specifically, the base excision repair pathway) are associated with bladder cancer risk. Some SNPs are associated with higher risk, others with lower risk. [PMID 17203305]
- rs125701 in the 8-oxoG DNA glycosylase OGG1 gene: variants are at decreased risk; the odds ratio is (95%CI) 0.78 (0.63-0.96)
- rs1136410 in the Poly (ADP-ribose) polymerase family member 1 PARP1 gene: variants are at increased risk; the odds ratio is (95%CI) 1.24 (1.02-1.51)
- rs3136717 in the POLB gene: variants are at increased risk; the odds ratio is (95%CI) 1.30 (1.04-1.62)
Other SNPs that have been associated with risk for (or resistance to) bladder cancer include:
See also cancer.