Have questions? Visit https://www.reddit.com/r/SNPedia

CYP3A7

From SNPedia
is agene
is mentioned by
Full namecytochrome P450, family 3, subfamily A, polypeptide 7
EntrezGene1551
PheGenI1551
VariationViewer1551
ClinVarCYP3A7
GeneCardsCYP3A7
dbSNP1551
DiseasesCYP3A7
SADR1551
HugeNav1551
CYPANCcyp3a7
wikipediaCYP3A7
googleCYP3A7
gopubmedCYP3A7
EVSCYP3A7
HEFalMpCYP3A7
MyGene2CYP3A7
23andMeCYP3A7
UniProtP24462
EnsemblENSG00000160870
OMIM605340
# SNPs3
 Max MagnitudeChromosome positionSummary
rs10211099,705,371
rs2257401099,709,062
rs4544669899,735,325

Located on chromosome 7, the CYP3A7 gene encodes an enzyme belonging to the cytochrome P450 family, sharing 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults.Wikipedia

In 2019, a publication reported that the CYP3A7*1C allele of the gene was associated with increased etonogestrel metabolism in adult females, with 27.8% (5/18) of CYP3A7*1C carriers having serum etonogestrel concentrations too low to respond consistently to a contraceptive implant intended to invoke ovulatory suppression (less than 90 pg/mL).10.1097/AOG.0000000000003189

This was not the first report of a consequence in adults of carrying the CYP3A7*1C allele; other findings include:

  • Lower (by 54%) urinary oestrone (E1) levels in premenopausal women, and a moderate increase in breast cancer mortality (HR, 1.74; p = 0.03), all-cause mortality in lung cancer patients (HR, 1.43; p = 0.009), and chronic lymphocytic leukemia (CLL) progression (HR, 1.62; p = 0.03).[PMID 26964624OA-icon.png]
  • Homozygous CYP3A7*1C carriers had significantly lower bone mineral density at the lumbar spine compared to wild types in a 2007 study based on 217 postmenopausal women with osteoporosis (and ~100 healthy women).[PMID 17334880]


The SNP that tags the CYP3A7*1C allele is rs45446698(C).