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Camptosar

From SNPedia


Camptosar is the trade name for irinotecan, a widely used drug in the treatment of colorectal cancer.

Side effects including severe diarrhea and neutropenia have been correlated to a variation in the UGT1A1 gene, which have led to FDA guidelines correlating the best dose of Camptosar to use depending on the patient's genotype.

Within the dbSNP database, there are multiple SNPs defining the same polymorphism; they are rs34815109, rs34983651, rs35600288 and rs5839491.