Cholinesterase Inhibitors

According to http://sites.google.com/site/annerwright/snps these SNPs may influence sensitivity to cholinesterase inhibitors:

• BCHE Gene:
  • rs1799807
  • rs28933389
  • rs28933390
  • rs1803274
• PON1 Gene:
  • rs854560
  • rs662
  • rs705379
  • rs705381
• CHAT Gene:
  • rs733722
• ADRB1 Gene:
  • rs1801252
• CHRNA3 Gene:
  • rs1051730
• CHRNA5 Gene:
  • rs16969968

Articles relevant to this topic include:

• [PMID 15060281] Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study
• [PMID 10814709] A transcription-activating polymorphism in the ACHE promoter associated with acute sensitivity to anti-acetylcholinesterases
• [PMID 16807370] Coding region paraoxonase polymorphisms dictate accentuated neuronal reactions in chronic, sub-threshold pesticide exposure.

Books relevant to this topic include:

• Cholinesterases and cholinesterase inhibitors, By Ezio Giacobini, Chapter 4