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FTO

From SNPedia
is agene
is mentioned by
Full namefat mass and obesity associated
EntrezGene79068
PheGenI79068
VariationViewer79068
ClinVarFTO
GeneCardsFTO
dbSNP79068
DiseasesFTO
SADR79068
HugeNav79068
wikipediaFTO
googleFTO
gopubmedFTO
EVSFTO
HEFalMpFTO
MyGene2FTO
23andMeFTO
UniProtQ9C0B1
EnsemblENSG00000140718
OMIM610966
# SNPs71
 Max MagnitudeChromosome positionSummary
rs10163409054,104,968
rs10852521053,771,053
rs11075990053,785,981
rs11075995053,821,379
rs11075996053,824,112
rs11075997053,825,000
rs11076008053,893,411
rs1108086054,066,457
rs1121980353,775,335
rs1164201553,768,582
rs11642841053,811,575
rs12149832053,808,996
rs121918214353,873,837
rs12595985053,842,839
rs12596210053,994,059
rs12597786053,787,395
rs12927155054,099,888
rs1420318054,068,854
rs1421084053,723,828
rs14210853.153,767,042obesity risk
rs1477196053,774,346
rs1558902053,769,662
rs16945088053,778,612
rs169530021.554,080,912
rs17219084053,821,688
rs17817449053,779,455
rs17817964053,794,154
rs17818902053,837,894
rs17820875053,892,878
rs1861868053,756,490
rs3751812053,784,548
rs3826169053,826,569
rs4784333053,935,176
rs5613703053,791,993
rs5710384953,844,521
rs6203340053,777,876
rs6204837953,763,271
rs6204840253,769,311
rs6499640053,735,765
rs7185735053,788,739
rs7190053053,840,745
rs7193144053,776,774
rs7195539053,825,246
rs7202116053,787,703
rs7204609053,799,693
rs78102886753,873,846
rs7920693953,826,140
rs8043757053,779,538
rs8044769053,805,223
rs8047395053,764,611
... further results
  • 2015 research suggests rs1421085 may be the causal variant blog summary
  • Within the FTO gene, rs9930506 showed the strongest association with BMI (p = 8.6 *10-7), hip circumference (p = 3.4 * 10-8) and weight (p = 9.1 * 10-7). homozygotes for the rare "G" allele were 1.3 BMI units heavier than homozygotes for the common "A" allele. More than 30 additional SNPs in or near the FTO gene were also studied, but they are co-inherited most of the time with the rs9930506 SNP and therefore are unlikely to represent independent risk factors. These co-inherited SNPs include rs1421085, rs9937053, rs8043757, rs3751812, rs9923233, rs9932754, and rs9922619. [PMID 17658951]
  • Note: The three FTO SNPs, rs1421085, rs17817449, and rs9939609, are in strong linkage disequilibrium (pairwise r2>0.97), and there are two primary haplotypes, C-G-A (42.0%; this is the haplotype representing obesity risk) and T-T-T (55.5%).
  • Another report fingers rs1121980 within the FTO gene as having the strongest association to early onset obesity compared to several other SNPs all in the same linkage block. [PMID 18159244]

The earlier study also had conclusions with regard to another gene:

  • Within the PFKP gene, rs6602024 showed very strong association with BMI (p = 4.9 * 10-6). Homozygotes for the rare "A" allele of this SNP (minor allele frequency = 0.12) were 1.8 BMI units heavier than homozygotes for the common "G" allele. They did not replicate association between rs6602024 and obesity-related traits in the GenNet sample, although they found that in European Americans, Hispanic Americans and African Americans, homozygotes for the rare "A" allele where, on average, 1.0 - 3.0 BMI units heavier than homozygotes for the more common "G" allele. [PMID 17658951]

[1] the FTO SNP rs9939609 is associated with changes in BMI and obesity in children by the age of 7 which persists into the pre-pubertal period and beyond.

http://varigenome.blogspot.com/2013/06/fto-and-memory-connecting-dots.html

“Genetic associations with traits in 23andMe customers.” 23andMe White Paper.