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Glyburide

From SNPedia
(Redirected from Glibenclamide)

Glibenclamide, also known as glyburide, is an antidiabetic drug in a class of medications known as sulfonylureas, closely related to sulfonamide antibiotics. It is used in the treatment of type-2 diabetes. As of 2003, in the United States, it was the most popular sulfonylurea.Wikipedia

PGx Table for Glyburide
Genotype/Genoset Diplotype Gene Drug Use/Category/Class Medical Field Summary Descriptive Sentence
gs309 WT/WT G6PD Diabetes Endocrinology Normal Response Expected You do not appear to carry any G6PD mutations linked to an unwanted side effect (hemolytic anemia).
gs307 Carrier G6PD Diabetes Endocrinology Consider Alternatives You carry a G6PD mutation that might lead to an unwanted side effect (hemolytic anemia) when taking glyburide; due to variable expression (i.e. in females), enzymatic testing for G6PD activity is advisable.
gs308 G6PD-deficient G6PD Diabetes Endocrinology Consider Alternatives You carry a G6PD mutation linked to an unwanted side effect (hemolytic anemia) when taking glyburide; use caution and consider non-sulfonylurea alternatives.