HLA
The HLA system is a number of antigens that make up the human class I and II Major Histocompatibility Complex (MHC), a regulator of the immune system important to organ compatibility and autoimmune diseases.
There are 6 major HLA antigen loci: Class I {A, B, C}, Class II {DP, DQ, DR}, determined by several genes with 1000s of variants. These combinations give rise to the HLA phenotypes and serotypes. An example result is phenotype: A*01:01/*03:01, C*07:01/*07:02, B*07:02/*08:01, DRB1*03:01/*15:01, DQA1*05:01/*01:02, DQB1*02:01/*06:02, with serotype: A1,A3,B7,B8,DR3,DR15(2),DQ2,DQ6(1). These can be classified into haplotypes, which relate to ancestry, such as 'super B8' in Western Europeans.
Variants are recorded in the IMGT-HLA database. Class I antigens have single genes, with minor variation in E, F, and G, while J, K and L are pseudogenes. Class II has α and β chains. DR has 4 β genes with ~400 combinations, while the α is functionally invariant. DM and DO affect antigen presentation. DP has been sequenced, but is less understood.
Contents
Allele frequencies in world populations[edit]
Total number of alleles per antigen locus[edit]
Locus | Total Variants |
---|---|
HLA-A | 2,884 |
HLA-B | 3,589 |
HLA-C | 2,375 |
HLA-DP | 16,036 |
HLA-DQ | 34,528 |
HLA-DR | 11,431 |
HLA-DO | 156 |
HLA-DM | 91 |
Tag SNPs for HLA antitypes on the 1M Illumina chip[edit]
HLA | SNP | r2 | HLA_FRQ | SNP_FRQ |
---|---|---|---|---|
A*01:02 | rs6902544 | 0.059 | 0.001 | 0.01 |
A*01:03 | rs6911622 | 0.008 | 0.001 | 0.06 |
A*02 | rs2394250 | 0.432 | 0.43 | |
A*02:01 | rs2975033 | 0.25 | ||
A*02:11 | rs16897572 | 0.019 | 0.003 | 0.08 |
A*02:16 | rs11754099 | 0.005 | 0.000 | 0.03 |
A*02:17 | rs1233400 | 0.003 | 0.001 | 0.16 |
A*03:02 | rs2523447 | 0.080 | 0.004 | 0.04 |
A*11:02 | rs2286404 | 0.013 | 0.001 | 0.06 |
A*11:03 | rs11754099 | 0.018 | 0.001 | 0.03 |
A*11:05 | rs3025642 | 0.005 | 0.000 | 0.04 |
A*24:01 | rs805284 | 0.007 | 0.000 | 0.03 |
A*24:03 | rs3093665 | 0.009 | 0.002 | 0.02 |
A*24:07 | rs2017525 | 0.044 | 0.005 | 0.10 |
A*24:10 | rs3129727 | 0.007 | 0.000 | 0.02 |
A*26:08 | rs2301751 | 0.007 | 0.000 | 0.05 |
A*30:04 | rs2857449 | 0.068 | 0.001 | 0.01 |
A*31:01 | rs1061235 | 0.085 | 0.08 | |
A*31:03 | rs6457694 | 0.008 | 0.000 | 0.02 |
A*31:12 | rs3895681 | 0.014 | 0.000 | 0.01 |
A*34:01 | rs6904120 | 0.079 | 0.010 | 0.06 |
A*34:02 | rs16895214 | 0.061 | 0.003 | 0.02 |
A*36:01 | rs2747419 | 0.040 | 0.001 | 0.02 |
A*36:03 | rs4713310 | 0.004 | 0.000 | 0.05 |
A*66:01 | rs9261316 | 0.064 | 0.004 | 0.05 |
A*66:02 | rs6906662 | 0.006 | 0.000 | 0.03 |
A*68:03 | rs4711248 | 0.046 | 0.001 | 0.01 |
A*69:01 | rs2517922 | 0.012 | 0.001 | 0.05 |
A*80:01 | rs2516312 | 0.015 | 0.001 | 0.01 |
B*07:04 | rs3104402 | 0.009 | 0.000 | 0.02 |
B*15:02 | rs2395148 | 0.025 | 0.003 | 0.03 |
B*15:03 | rs7742033 | 0.054 | 0.005 | 0.02 |
B*15:04 | rs9391714 | 0.009 | 0.000 | 0.03 |
B*15:05 | rs6903896 | 0.004 | 0.000 | 0.03 |
B*15:06 | rs9500864 | 0.008 | 0.000 | 0.02 |
B*15:07 | rs17493811 | 0.016 | 0.001 | 0.04 |
B*15:08 | rs9357117 | 0.027 | 0.001 | 0.02 |
B*15:09 | rs16899178 | 0.007 | 0.000 | 0.05 |
B*15:10 | rs3093542 | 0.043 | 0.002 | 0.02 |
B*15:13 | rs9357117 | 0.041 | 0.001 | 0.02 |
B*15:15 | rs2021783 | 0.018 | 0.000 | 0.01 |
B*15:16 | rs3218822 | 0.014 | 0.001 | 0.02 |
B*15:18 | rs16899178 | 0.033 | 0.003 | 0.05 |
B*15:21 | rs6902544 | 0.069 | 0.001 | 0.01 |
B*15:24 | rs3895681 | 0.015 | 0.000 | 0.01 |
B*15:25 | rs2859110 | 0.017 | 0.001 | 0.01 |
B*15:26 | rs3763288 | 0.021 | 0.002 | 0.09 |
B*15:27 | rs3817964 | 0.003 | 0.000 | 0.06 |
B*15:30 | rs9405015 | 0.009 | 0.000 | 0.02 |
B*18:02 | rs12662077 | 0.010 | 0.001 | 0.05 |
B*27 | rs13202464 | 0.071 | 0.07 | |
B*27:03 | rs9366775 | 0.007 | 0.000 | 0.03 |
B*27:04 | rs3819299 | 0.023 | 0.001 | 0.06 |
B*27:07 | rs3093671 | 0.021 | 0.001 | 0.03 |
B*35:02 | rs2073724 | 0.058 | 0.010 | 0.08 |
B*35:05 | rs2073724 | 0.032 | 0.003 | 0.08 |
B*35:12 | rs3093561 | 0.086 | 0.001 | 0.01 |
B*35:14 | rs2517623 | 0.018 | 0.000 | 0.01 |
B*35:17 | rs3093561 | 0.029 | 0.001 | 0.01 |
B*35:21 | rs7761890 | 0.009 | 0.000 | 0.02 |
B*35:43 | rs9366775 | 0.012 | 0.000 | 0.03 |
B*38:02 | rs2233954 | 0.049 | 0.004 | 0.05 |
B*39:01 | rs6910087 | 0.060 | 0.010 | 0.16 |
B*39:02 | rs7761890 | 0.006 | 0.000 | 0.02 |
B*39:08 | rs4711250 | 0.015 | 0.000 | 0.01 |
B*39:09 | rs2071288 | 0.011 | 0.001 | 0.01 |
B*39:10 | rs9469093 | 0.008 | 0.001 | 0.02 |
B*40:05 | rs16899178 | 0.006 | 0.000 | 0.05 |
B*40:09 | rs3093561 | 0.014 | 0.000 | 0.01 |
B*40:10 | rs35759989 | 0.005 | 0.000 | 0.03 |
B*40:23 | rs2021783 | 0.018 | 0.000 | 0.01 |
B*42:02 | rs9468942 | 0.047 | 0.001 | 0.01 |
B*44:04 | rs3130666 | 0.016 | 0.000 | 0.02 |
B*45:01 | rs2523477 | 0.087 | 0.010 | 0.08 |
B*48:01 | rs3093668 | 0.052 | 0.003 | 0.02 |
B*50:02 | rs915653 | 0.010 | 0.000 | 0.02 |
B*51 | rs79556279 | 0.0573 | 0.05 | |
B*51:02 | rs3093561 | 0.038 | 0.001 | 0.01 |
B*51:05 | rs3093665 | 0.021 | 0.000 | 0.02 |
B*51:06 | rs6903896 | 0.017 | 0.001 | 0.03 |
B*51:08 | rs7747738 | 0.017 | 0.001 | 0.03 |
B*54:01 | rs3819284 | 0.077 | 0.002 | 0.02 |
B*56:03 | rs2021783 | 0.018 | 0.000 | 0.01 |
B*56:04 | rs3819284 | 0.019 | 0.000 | 0.02 |
B*57 | rs2395029 | 0.057 | 0.05 | |
B*57:02 | rs9296020 | 0.033 | 0.03 | |
B*57:03 | rs9468559 | 0.007 | 0.001 | 0.02 |
B*58:02 | rs6902738 | 0.053 | 0.002 | 0.01 |
B*73:01 | rs2071288 | 0.060 | 0.001 | 0.01 |
B*78:01 | rs7747738 | 0.017 | 0.001 | 0.03 |
B*81:01 | rs9263582 | 0.014 | 0.001 | 0.05 |
C*02:06 | rs3093671 | 0.006 | 0.000 | 0.03 |
C*03:05 | rs3093561 | 0.003 | 0.000 | 0.01 |
C*03:06 | rs2517490 | 0.007 | 0.000 | 0.02 |
C*04:03 | rs2269713 | 0.039 | 0.003 | 0.04 |
C*04:04 | rs2074475 | 0.006 | 0.000 | 0.02 |
C*04:07 | rs7774197 | 0.003 | 0.000 | 0.05 |
C*04:10 | rs3819284 | 0.010 | 0.000 | 0.02 |
C*06:02 | rs10484554 | 0.11 | ||
C*07:26 | rs9296020 | 0.009 | 0.000 | 0.01 |
C*08:01 | rs2524083 | 0.071 | 0.010 | 0.12 |
C*12:04 | rs28732150 | 0.015 | 0.001 | 0.05 |
C*15:04 | rs16899178 | 0.031 | 0.002 | 0.05 |
C*16:04 | rs7747738 | 0.059 | 0.002 | 0.03 |
C*18:01 | rs7759127 | 0.015 | 0.002 | 0.12 |
DPA1*01:04 | rs11751659 | 0.062 | 0.010 | 0.11 |
DPA1*01:05 | rs9468942 | 0.010 | 0.001 | 0.01 |
DPA1*02:02 | rs1431403 | 0.077 | 0.060 | 0.34 |
DPA1*03:01 | rs9468559 | 0.030 | 0.010 | 0.02 |
DPA1*04:01 | rs7763822 | 0.016 | 0.003 | 0.04 |
DPB1*15:01 | rs11751659 | 0.083 | 0.010 | 0.11 |
DPB1*16:01 | rs3129270 | 0.039 | 0.010 | 0.12 |
DPB1*18:01 | rs448733 | 0.017 | 0.002 | 0.05 |
DPB1*19:01 | rs3128935 | 0.029 | 0.003 | 0.06 |
DPB1*20:01 | rs3129270 | 0.032 | 0.004 | 0.12 |
DPB1*21:01 | rs2021783 | 0.013 | 0.001 | 0.01 |
DPB1*22:01 | rs9368704 | 0.003 | 0.000 | 0.01 |
DPB1*26:01 | rs6930052 | 0.040 | 0.004 | 0.05 |
DPB1*28:01 | rs9469378 | 0.024 | 0.001 | 0.05 |
DPB1*30:01 | rs2736182 | 0.004 | 0.000 | 0.05 |
DPB1*31:01 | rs9368704 | 0.011 | 0.000 | 0.01 |
DPB1*33:01 | rs2517490 | 0.007 | 0.000 | 0.02 |
DPB1*34:01 | rs3130609 | 0.006 | 0.000 | 0.04 |
DPB1*35:01 | rs6937061 | 0.008 | 0.000 | 0.04 |
DPB1*40:01 | rs6930217 | 0.012 | 0.001 | 0.01 |
DPB1*45:01 | rs6937061 | 0.008 | 0.000 | 0.04 |
DPB1*48:01 | rs2021783 | 0.018 | 0.000 | 0.01 |
DPB1*81:01 | rs9469063 | 0.006 | 0.000 | 0.03 |
DPB1*85:01 | rs9468559 | 0.021 | 0.001 | 0.02 |
DQB1*03:04 | rs17501267 | 0.072 | 0.003 | 0.04 |
DQB1*03:05 | rs11759238 | 0.006 | 0.000 | 0.02 |
DQB1*04:01 | rs9368704 | 0.033 | 0.003 | 0.01 |
DQB1*05:04 | rs28732193 | 0.054 | 0.001 | 0.02 |
DRB1*03:01 | rs2187668 | 0.077 | 0.08 | |
DRB1*03:04 | rs2517623 | 0.004 | 0.000 | 0.01 |
DRB1*04:03 | rs3763305 | 0.061 | 0.010 | 0.06 |
DRB1*04:06 | rs9391637 | 0.011 | 0.001 | 0.01 |
DRB1*04:07 | rs4947332 | 0.047 | 0.010 | 0.02 |
DRB1*04:08 | rs17501267 | 0.077 | 0.010 | 0.04 |
DRB1*04:09 | rs9267658 | 0.003 | 0.000 | 0.06 |
DRB1*04:10 | rs6902544 | 0.007 | 0.000 | 0.01 |
DRB1*04:11 | rs3817964 | 0.010 | 0.001 | 0.06 |
DRB1*04:37 | rs7742120 | 0.003 | 0.000 | 0.07 |
DRB1*08:02 | rs9501626 | 0.039 | 0.004 | 0.09 |
DRB1*08:03 | rs2395148 | 0.039 | 0.003 | 0.03 |
DRB1*08:04 | rs7356880 | 0.066 | 0.003 | 0.03 |
DRB1*08:06 | rs9469063 | 0.013 | 0.000 | 0.03 |
DRB1*11:02 | rs28366191 | 0.016 | 0.003 | 0.05 |
DRB1*11:03 | rs17208888 | 0.052 | 0.004 | 0.07 |
DRB1*11:04 | rs17208888 | 0.059 | 0.010 | 0.07 |
DRB1*11:06 | rs11754099 | 0.011 | 0.001 | 0.03 |
DRB1*11:08 | rs9469024 | 0.017 | 0.000 | 0.01 |
DRB1*12:01 | rs3129888 | 0.054 | 0.010 | 0.10 |
DRB1*13:04 | rs3130666 | 0.012 | 0.000 | 0.02 |
DRB1*13:05 | rs17208888 | 0.010 | 0.001 | 0.07 |
DRB1*14:02 | rs7761890 | 0.017 | 0.002 | 0.02 |
DRB1*14:05 | rs3129727 | 0.011 | 0.000 | 0.02 |
DRB1*14:06 | rs12055568 | 0.017 | 0.001 | 0.03 |
DRB1*14:07 | rs11575840 | 0.012 | 0.000 | 0.02 |
DRB1*14:15 | rs3129727 | 0.016 | 0.000 | 0.02 |
DRB1*15:01 | rs9271366 | 0.15 | ||
DRB1*16:02 | rs9270986 | 0.034 | 0.003 | 0.09 |
Variants associated with frequent haplotypes in Europeans[edit]
Source: [PMID 24988075]
Tag SNP haplotypes for Hapmap 1 populations[edit]
source: Broad Institute Tagger
Pop. | HLA allele | frequency | tag SNP haplotype | frequency | rsquared | dprime |
---|---|---|---|---|---|---|
CEU | HLA-A*0101 | 0.189 | rs1611635(T) & rs10947088(T) | 0.183 | 0.964 | 1.00 |
CEU | HLA-A*0201 | 0.328 | rs2844821(G) & rs762324(C) | 0.350 | 0.906 | 1.00 |
CEU | HLA-A*0205 | 0.011 | rs6906270(C) | 0.011 | 1.000 | 1.00 |
CEU | HLA-A*0206 | 0.006 | rs3116820(G) & rs6457109(G) | 0.011 | 0.497 | 1.00 |
CEU | HLA-A*0301 | 0.094 | rs9380122(T) & rs9259817(C) | 0.100 | 0.939 | 1.00 |
CEU | HLA-A*1101 | 0.039 | rs29233(C) | 0.039 | 1.000 | 1.00 |
CEU | HLA-A*2301 | 0.017 | rs3025623(T) & rs2534825(G) | 0.017 | 1.000 | 1.00 |
CEU | HLA-A*2402 | 0.089 | rs3893538(C) & rs2523933(A) | 0.094 | 0.935 | 1.00 |
CEU | HLA-A*2403 | 0.006 | rs362527(G) & rs4071986(T) | 0.011 | 0.497 | 1.00 |
CEU | HLA-A*2501 | 0.039 | rs3835309(A) & rs3094121(A) | 0.039 | 1.000 | 1.00 |
CEU | HLA-A*2601 | 0.022 | rs2301751(T) & rs4678(C) | 0.022 | 1.000 | 1.00 |
CEU | HLA-A*2902 | 0.017 | rs7453068(A) & rs2844659(A) | 0.017 | 1.000 | 1.00 |
CEU | HLA-A*3001 | 0.006 | rs11961013(G) | 0.006 | 1.000 | 1.00 |
CEU | HLA-A*3002 | 0.006 | rs29243(C) | 0.006 | 1.000 | 1.00 |
CEU | HLA-A*3101 | 0.033 | rs1061235(T) | 0.033 | 1.000 | 1.00 |
CEU | HLA-A*3201 | 0.028 | rs1611578(G) & rs3130244(C) | 0.028 | 1.000 | 1.00 |
CEU | HLA-A*6801 | 0.033 | rs1610714(G) & rs2571375(G) | 0.033 | 1.000 | 1.00 |
CEU | HLA-B*0702 | 0.183 | rs2596438(G) & rs805288(C) | 0.189 | 0.964 | 1.00 |
CEU | HLA-B*0801 | 0.139 | rs6457374(G) & rs2844535(C) | 0.139 | 0.909 | 0.95 |
CEU | HLA-B*1302 | 0.017 | rs12191164(G) | 0.017 | 1.000 | 1.00 |
CEU | HLA-B*1401 | 0.006 | rs12208550(G) | 0.006 | 1.000 | 1.00 |
CEU | HLA-B*1402 | 0.011 | rs2524160(T) & rs9368673(C) | 0.011 | 1.000 | 1.00 |
CEU | HLA-B*1501 | 0.072 | rs3094117(A) & rs3819294(A) | 0.067 | 0.918 | 1.00 |
CEU | HLA-B*1510 | 0.006 | rs11969139(T) | 0.006 | 1.000 | 1.00 |
CEU | HLA-B*1801 | 0.039 | rs3129996(G) & rs2523589(G) & rs2844575(C) | 0.039 | 1.000 | 1.00 |
CEU | HLA-B*2705 | 0.006 | rs6919835(G) | 0.011 | 0.497 | 0.99 |
CEU | HLA-B*3501 | 0.050 | rs2532934(A) & rs3905495(A) & rs2523685(G) | 0.050 | 1.000 | 1.00 |
CEU | HLA-B*3503 | 0.011 | rs1264375(C) & rs1058026(C) & rs2857605(T) | 0.011 | 1.000 | 1.00 |
CEU | HLA-B*3701 | 0.011 | rs2853931(A) & rs7772218(G) | 0.011 | 1.000 | 1.00 |
CEU | HLA-B*3801 | 0.006 | rs2734331(G) & rs3129944(G) | 0.011 | 0.497 | 1.00 |
CEU | HLA-B*3905 | 0.006 | rs3131382(G) | 0.006 | 1.000 | 1.00 |
CEU | HLA-B*3906 | 0.011 | rs9468859(A) & rs2844603(A) | 0.011 | 1.000 | 1.00 |
CEU | HLA-B*4001 | 0.039 | rs4711240(G) & rs1265110(A) | 0.039 | 1.000 | 1.00 |
CEU | HLA-B*4002 | 0.017 | rs3819285(C) | 0.017 | 1.000 | 1.00 |
CEU | HLA-B*4101 | 0.006 | rs2269708(T) | 0.006 | 1.000 | 1.00 |
CEU | HLA-B*4402 | 0.122 | rs3130501(C) & rs2769(T) & rs2844533(T) | 0.128 | 0.950 | 1.00 |
CEU | HLA-B*4403 | 0.022 | rs12526186(C) & rs7747738(A) | 0.022 | 1.000 | 1.00 |
CEU | HLA-B*4404 | 0.006 | rs2524180(T) & rs7747738(A) | 0.011 | 0.497 | 1.00 |
CEU | HLA-B*4405 | 0.006 | rs2516683(C) & rs2844685(T) | 0.011 | 0.497 | 1.00 |
CEU | HLA-B*4901 | 0.011 | rs2394985(G) | 0.011 | 1.000 | 1.00 |
CEU | HLA-B*5001 | 0.017 | rs915653(T) | 0.017 | 1.000 | 1.00 |
CEU | HLA-B*5101 | 0.028 | rs2516675(C) & rs2844657(T) & rs4947296(C) | 0.033 | 0.829 | 1.00 |
CEU | HLA-B*5201 | 0.017 | rs2517424(A) & rs12526820(C) | 0.017 | 1.000 | 1.00 |
CEU | HLA-B*5601 | 0.011 | rs4122190(A) | 0.011 | 1.000 | 1.00 |
CEU | HLA-B*5701 | 0.061 | rs2395029(T) | 0.061 | 1.000 | 1.00 |
CEU | HLA-B*5801 | 0.006 | rs3130660(A) & rs1063635(A) | 0.011 | 0.497 | 1.00 |
CEU | HLA-C*0102 | 0.017 | rs9380234(C) | 0.017 | 1.000 | 1.00 |
CEU | HLA-C*0202 | 0.022 | rs1265100(G) & rs4122189(C) | 0.022 | 1.000 | 1.00 |
CEU | HLA-C*0303 | 0.061 | rs1265100(A) & rs7745906(A) | 0.056 | 0.904 | 1.00 |
CEU | HLA-C*0304 | 0.039 | rs4713391(C) & rs7745906(A) & rs3130434(C) | 0.039 | 1.000 | 1.00 |
CEU | HLA-C*0401 | 0.083 | rs9461684(G) | 0.083 | 1.000 | 1.00 |
CEU | HLA-C*0501 | 0.117 | rs3130955(C) & rs364415(A) & rs4151665(C) | 0.117 | 1.000 | 1.00 |
CEU | HLA-C*0602 | 0.117 | rs887466(G) & rs4379333(C) | 0.117 | 1.000 | 1.00 |
CEU | HLA-C*0701 | 0.178 | rs2524074(C) & rs7382297(C) | 0.178 | 0.925 | 0.96 |
CEU | HLA-C*0702 | 0.206 | rs3132572(A) & rs2001181(A) | 0.217 | 0.935 | 0.99 |
CEU | HLA-C*0704 | 0.028 | rs2524050(T) & rs2256583(G) | 0.028 | 1.000 | 1.00 |
CEU | HLA-C*0802 | 0.017 | rs2524048(G) & rs2442719(G) | 0.017 | 1.000 | 1.00 |
CEU | HLA-C*1202 | 0.011 | rs3869115(C) & rs396960(T) | 0.011 | 1.000 | 1.00 |
CEU | HLA-C*1203 | 0.017 | rs3130457(A) & rs2248902(T) | 0.017 | 1.000 | 1.00 |
CEU | HLA-C*1402 | 0.017 | rs2517439(A) & rs2240061(C) | 0.017 | 1.000 | 1.00 |
CEU | HLA-C*1502 | 0.028 | rs3764808(G) & rs4379333(C) | 0.028 | 1.000 | 1.00 |
CEU | HLA-C*1601 | 0.033 | rs7747738(G) | 0.028 | 0.829 | 0.99 |
CEU | HLA-C*1701 | 0.006 | rs2269708(T) | 0.006 | 1.000 | 1.00 |
CEU | HLA-DQA*0101 | 0.133 | rs6457614(A) & rs1794265(G) | 0.133 | 1.000 | 1.00 |
CEU | HLA-DQA*0102 | 0.239 | rs14004(G) & rs6457594(A) | 0.228 | 0.881 | 0.97 |
CEU | HLA-DQA*0103 | 0.056 | rs2273017(A) & rs2157051(G) | 0.050 | 0.895 | 1.00 |
CEU | HLA-DQA*0201 | 0.133 | rs7745002(C) & rs2858333(G) & 6p0315(G) | 0.133 | 0.906 | 0.95 |
CEU | HLA-DQA*0301 | 0.228 | rs3129883(C) & rs7745002(C) & rs3844313(G) | 0.228 | 1.000 | 1.00 |
CEU | HLA-DQA*0401 | 0.033 | rs7743506(C) | 0.033 | 1.000 | 1.00 |
CEU | HLA-DQA*0501 | 0.178 | rs10485326(T) & rs2040406(A) | 0.172 | 0.962 | 0.99 |
CEU | HLA-DQB*0201 | 0.156 | rs4988889(G) | 0.150 | 0.958 | 0.99 |
CEU | HLA-DQB*0301 | 0.167 | rs7744001(A) & rs2856691(C) | 0.167 | 1.000 | 1.00 |
CEU | HLA-DQB*0302 | 0.144 | rs7454108(C) & rs2071876(C) | 0.144 | 1.000 | 1.00 |
CEU | HLA-DQB*0303 | 0.061 | rs3834857(C) & rs2395533(T) | 0.061 | 1.000 | 1.00 |
CEU | HLA-DQB*0305 | 0.006 | rs9267532(A) & rs707915(A) | 0.011 | 0.497 | 1.00 |
CEU | HLA-DQB*0402 | 0.033 | rs7743506(C) | 0.033 | 1.000 | 1.00 |
CEU | HLA-DQB*0501 | 0.094 | rs6457614(A) | 0.094 | 1.000 | 1.00 |
CEU | HLA-DQB*0502 | 0.022 | rs1548306(A) & rs5875391(A) | 0.022 | 1.000 | 1.00 |
CEU | HLA-DQB*0503 | 0.039 | rs1794265(G) | 0.039 | 1.000 | 1.00 |
CEU | HLA-DQB*0601 | 0.006 | rs2858880(A) | 0.006 | 1.000 | 1.00 |
CEU | HLA-DQB*0602 | 0.200 | rs3135388(G) | 0.206 | 0.966 | 0.99 |
CEU | HLA-DQB*0603 | 0.050 | rs2395150(T) & rs3135461(G) | 0.050 | 1.000 | 1.00 |
CEU | HLA-DQB*0604 | 0.017 | rs10573(A) & rs7766854(A) | 0.017 | 1.000 | 1.00 |
CEU | HLA-DQB*0609 | 0.006 | rs6901092(A) | 0.006 | 1.000 | 1.00 |
CEU | HLA-DRB*0101 | 0.089 | rs4947332(G) & rs6457614(C) | 0.089 | 1.000 | 1.00 |
CEU | HLA-DRB*0301 | 0.094 | rs2040410(G) | 0.083 | 0.872 | 0.99 |
CEU | HLA-DRB*0401 | 0.089 | rs6910071(C) & rs3817964(A) & rs660895(C) | 0.117 | 0.739 | 1.00 |
CEU | HLA-DRB*0402 | 0.006 | rs3130071(T) & rs416352(A) | 0.011 | 0.497 | 1.00 |
CEU | HLA-DRB*0403 | 0.017 | rs7454108(C) & rs206765(A) & rs399604(C) | 0.017 | 1.000 | 1.00 |
CEU | HLA-DRB*0404 | 0.106 | rs2736157(A) & rs3115572(C) & rs2395533(T) | 0.128 | 0.623 | 0.88 |
CEU | HLA-DRB*0405 | 0.006 | rs1057149(C) | 0.011 | 0.497 | 0.99 |
CEU | HLA-DRB*0407 | 0.011 | rs7774197(G) & rs417812(T) | 0.011 | 1.000 | 1.00 |
CEU | HLA-DRB*0701 | 0.100 | rs7745002(C) & rs2647087(G) & rs241398(C) | 0.117 | 0.739 | 0.94 |
CEU | HLA-DRB*0801 | 0.033 | rs7743506(C) | 0.033 | 1.000 | 1.00 |
CEU | HLA-DRB*1001 | 0.006 | rs4148871(T) & rs2071538(A) | 0.011 | 0.497 | 1.00 |
CEU | HLA-DRB*1101 | 0.050 | rs434841(G) & rs1061172(G) & rs5875439(G) | 0.050 | 1.000 | 1.00 |
CEU | HLA-DRB*1103 | 0.011 | rs4639334(T) & rs412735(A) & rs210180(T) | 0.011 | 1.000 | 1.00 |
CEU | HLA-DRB*1104 | 0.006 | rs4713607(A) & rs12664430(A) | 0.011 | 0.497 | 1.00 |
CEU | HLA-DRB*1201 | 0.006 | rs6901541(C) & rs6916742(A) | 0.011 | 0.497 | 1.00 |
CEU | HLA-DRB*1301 | 0.044 | rs2395173(G) & rs2157051(G) | 0.050 | 0.884 | 1.00 |
CEU | HLA-DRB*1302 | 0.022 | rs4434496(T) & rs6901541(T) | 0.022 | 1.000 | 1.00 |
CEU | HLA-DRB*1303 | 0.011 | rs424232(A) & rs2050191(A) | 0.011 | 1.000 | 1.00 |
CEU | HLA-DRB*1401 | 0.033 | rs2763979(G) & rs1794265(C) | 0.033 | 1.000 | 1.00 |
CEU | HLA-DRB*1404 | 0.006 | rs805262(G) & rs1794265(C) | 0.011 | 0.497 | 1.00 |
CEU | HLA-DRB*1501 | 0.200 | rs3135388(G) | 0.206 | 0.966 | 0.99 |
CEU | HLA-DRB*1502 | 0.006 | rs2858880(A) | 0.006 | 1.000 | 1.00 |
CEU | HLA-DRB*1601 | 0.022 | rs7452076(T) & rs6923504(G) | 0.022 | 1.000 | 1.00 |
YRI | HLA-A*0101 | 0.017 | rs10807055(A) & rs2844775(A) | 0.017 | 1.000 | 1.00 |
YRI | HLA-A*0201 | 0.042 | rs4713240(G) & rs3132682(C) | 0.042 | 1.000 | 1.00 |
YRI | HLA-A*0202 | 0.025 | rs9261488(T) & rs3094636(C) | 0.025 | 1.000 | 1.00 |
YRI | HLA-A*0205 | 0.017 | rs2523734(G) & rs3132672(T) | 0.017 | 1.000 | 1.00 |
YRI | HLA-A*0211 | 0.008 | rs7452887(C) & rs968909(A) | 0.017 | 0.496 | 1.00 |
YRI | HLA-A*0301 | 0.125 | rs2524024(A) | 0.125 | 1.000 | 1.00 |
YRI | HLA-A*2301 | 0.108 | rs2524024(A) | 0.108 | 1.000 | 1.00 |
YRI | HLA-A*2424 | 0.008 | rs1264362(C) | 0.017 | 0.496 | 0.99 |
YRI | HLA-A*2601 | 0.025 | rs3823339(G) | 0.025 | 1.000 | 1.00 |
YRI | HLA-A*2902 | 0.017 | rs7741100(G) & rs2523807(C) | 0.017 | 1.000 | 1.00 |
YRI | HLA-A*3001 | 0.092 | rs1633005(T) & rs2057727(T) | 0.092 | 1.000 | 1.00 |
YRI | HLA-A*3002 | 0.050 | rs2844846(A) & rs2517671(C) | 0.050 | 1.000 | 1.00 |
YRI | HLA-A*3201 | 0.008 | rs3873243(C) | 0.008 | 1.000 | 1.00 |
YRI | HLA-A*3301 | 0.025 | rs7749944(T) | 0.025 | 1.000 | 1.00 |
YRI | HLA-A*3303 | 0.108 | rs6921921(A) & rs2523945(G) | 0.108 | 1.000 | 1.00 |
YRI | HLA-A*3402 | 0.042 | rs1610606(C) & rs4959036(G) | 0.042 | 1.000 | 1.00 |
YRI | HLA-A*3601 | 0.142 | rs259940(G) & rs261943(G) | 0.142 | 1.000 | 1.00 |
YRI | HLA-A*6602 | 0.017 | rs3115592(A) & rs2523960(G) | 0.017 | 1.000 | 1.00 |
YRI | HLA-A*6801 | 0.017 | rs2735068(C) & rs2524198(C) | 0.017 | 1.000 | 1.00 |
YRI | HLA-A*6802 | 0.058 | rs6457116(C) | 0.058 | 1.000 | 1.00 |
YRI | HLA-A*7401 | 0.042 | rs9468675(C) | 0.042 | 1.000 | 1.00 |
YRI | HLA-A*8001 | 0.008 | rs1235162(T) | 0.008 | 1.000 | 1.00 |
YRI | HLA-B*0702 | 0.075 | rs2523618(T) | 0.075 | 1.000 | 1.00 |
YRI | HLA-B*0801 | 0.008 | rs1059612(C) | 0.008 | 1.000 | 1.00 |
YRI | HLA-B*1302 | 0.025 | rs397596(A) | 0.025 | 1.000 | 1.00 |
YRI | HLA-B*1401 | 0.008 | rs1264308(C) | 0.017 | 0.496 | 0.99 |
YRI | HLA-B*1402 | 0.008 | rs2734331(A) | 0.008 | 1.000 | 1.00 |
YRI | HLA-B*1403 | 0.008 | rs2524229(T) | 0.017 | 0.496 | 0.99 |
YRI | HLA-B*1503 | 0.058 | rs3819294(A) & rs2844533(C) | 0.058 | 1.000 | 1.00 |
YRI | HLA-B*1510 | 0.083 | rs3819294(A) & rs2523638(G) | 0.083 | 1.000 | 1.00 |
YRI | HLA-B*1516 | 0.008 | rs7776044(A) & rs2736157(G) | 0.017 | 0.496 | 1.00 |
YRI | HLA-B*1801 | 0.050 | rs1051791(C) | 0.050 | 1.000 | 1.00 |
YRI | HLA-B*3501 | 0.083 | rs2249876(T) & rs1058026(C) & rs2844498(C) | 0.083 | 1.000 | 1.00 |
YRI | HLA-B*3903 | 0.008 | rs3094111(A) & rs2233969(G) | 0.017 | 0.496 | 1.00 |
YRI | HLA-B*3910 | 0.008 | rs6929434(T) | 0.008 | 1.000 | 1.00 |
YRI | HLA-B*4201 | 0.075 | rs5875311(G) & rs2273017(G) | 0.075 | 1.000 | 1.00 |
YRI | HLA-B*4202 | 0.008 | rs9469052(C) | 0.017 | 0.496 | 0.99 |
YRI | HLA-B*4403 | 0.017 | rs2769(C) | 0.017 | 1.000 | 1.00 |
YRI | HLA-B*4501 | 0.017 | rs7453631(T) | 0.017 | 1.000 | 1.00 |
YRI | HLA-B*4901 | 0.050 | rs9368673(C) & rs11967289(T) | 0.050 | 1.000 | 1.00 |
YRI | HLA-B*5101 | 0.042 | rs2523451(T) & rs4569(G) & rs379464(G) | 0.033 | 0.793 | 1.00 |
YRI | HLA-B*5201 | 0.083 | rs2394401(A) & rs7747738(A) & rs2256965(T) | 0.083 | 1.000 | 1.00 |
YRI | HLA-B*5301 | 0.158 | rs2844535(C) & rs6940467(G) | 0.150 | 0.938 | 1.00 |
YRI | HLA-B*5601 | 0.008 | rs4122190(A) | 0.008 | 1.000 | 1.00 |
YRI | HLA-B*5702 | 0.008 | rs2246626(G) & rs2071278(G) | 0.017 | 0.496 | 1.00 |
YRI | HLA-B*5703 | 0.025 | rs7451258(C) & rs3998357(G) & rs2523586(T) | 0.025 | 1.000 | 1.00 |
YRI | HLA-B*5801 | 0.058 | rs1058026(A) & rs2523608(T) & rs6929932(T) | 0.067 | 0.867 | 1.00 |
YRI | HLA-B*7801 | 0.008 | rs3130116(T) | 0.017 | 0.496 | 0.99 |
YRI | HLA-B*8101 | 0.008 | rs9261947(A) & rs2853925(C) | 0.017 | 0.496 | 1.00 |
YRI | HLA-C*0102 | 0.008 | rs4122190(A) | 0.008 | 1.000 | 1.00 |
YRI | HLA-C*0202 | 0.092 | rs6923313(G) & rs2243868(G) | 0.092 | 1.000 | 1.00 |
YRI | HLA-C*0302 | 0.042 | rs2074488(G) | 0.042 | 1.000 | 1.00 |
YRI | HLA-C*0401 | 0.250 | rs4386816(T) | 0.250 | 1.000 | 1.00 |
YRI | HLA-C*0501 | 0.008 | rs7762619(T) | 0.008 | 1.000 | 1.00 |
YRI | HLA-C*0602 | 0.008 | rs12198655(G) | 0.017 | 0.496 | 0.99 |
YRI | HLA-C*0701 | 0.133 | rs3132499(A) & rs2524074(C) | 0.133 | 1.000 | 1.00 |
YRI | HLA-C*0702 | 0.058 | rs9264731(A) | 0.058 | 1.000 | 1.00 |
YRI | HLA-C*0802 | 0.050 | rs2524100(G) & rs652888(A) | 0.050 | 1.000 | 1.00 |
YRI | HLA-C*0804 | 0.050 | rs1265180(A) & rs2523554(G) | 0.050 | 1.000 | 1.00 |
YRI | HLA-C*1203 | 0.008 | rs6929434(T) | 0.008 | 1.000 | 1.00 |
YRI | HLA-C*1402 | 0.008 | rs6457259(C) & rs2535293(C) | 0.017 | 0.496 | 1.00 |
YRI | HLA-C*1505 | 0.017 | rs3216869(C) & rs7381371(T) | 0.017 | 1.000 | 1.00 |
YRI | HLA-C*1601 | 0.167 | rs2844603(G) & rs2844586(A) | 0.167 | 0.884 | 0.94 |
YRI | HLA-C*1701 | 0.083 | rs2524069(A) & rs5875311(G) & rs3096702(C) | 0.075 | 0.892 | 1.00 |
YRI | HLA-C*1801 | 0.017 | rs2524040(G) & rs2524089(G) | 0.017 | 1.000 | 1.00 |
YRI | HLA-DQA*0101 | 0.100 | rs3134605(A) & rs2858330(A) & rs1612904(A) | 0.108 | 0.915 | 1.00 |
YRI | HLA-DQA*0102 | 0.242 | rs204996(G) & rs6457594(A) & rs1063355(A) | 0.233 | 0.704 | 0.86 |
YRI | HLA-DQA*0103 | 0.083 | rs3135338(A) & rs2858867(T) & rs5875382(A) | 0.083 | 1.000 | 1.00 |
YRI | HLA-DQA*0201 | 0.150 | rs3844313(A) & rs2647012(C) | 0.150 | 1.000 | 1.00 |
YRI | HLA-DQA*0301 | 0.058 | rs5875382(G) & rs6457617(A) | 0.058 | 1.000 | 1.00 |
YRI | HLA-DQA*0401 | 0.133 | rs4639334(C) & rs1061172(G) | 0.133 | 1.000 | 1.00 |
YRI | HLA-DQA*0501 | 0.233 | rs4424079(G) & rs2284189(A) | 0.233 | 0.822 | 0.91 |
YRI | HLA-DQB*0201 | 0.275 | rs4988889(G) | 0.275 | 1.000 | 1.00 |
YRI | HLA-DQB*0301 | 0.175 | rs6928482(G) & rs1056315(A) | 0.175 | 1.000 | 1.00 |
YRI | HLA-DQB*0302 | 0.017 | rs7454108(T) | 0.017 | 1.000 | 1.00 |
YRI | HLA-DQB*0402 | 0.108 | rs2213586(T) & rs4947342(T) | 0.108 | 1.000 | 1.00 |
YRI | HLA-DQB*0501 | 0.125 | rs6457614(A) | 0.125 | 1.000 | 1.00 |
YRI | HLA-DQB*0502 | 0.058 | rs3129718(G) | 0.058 | 1.000 | 1.00 |
YRI | HLA-DQB*0503 | 0.025 | rs1612904(A) & rs2856717(T) | 0.025 | 1.000 | 1.00 |
YRI | HLA-DQB*0602 | 0.100 | rs5875382(G) & rs3134975(T) | 0.117 | 0.841 | 1.00 |
YRI | HLA-DQB*0603 | 0.058 | rs3135006(T) & rs3918153(C) & rs210139(G) | 0.067 | 0.867 | 1.00 |
YRI | HLA-DQB*0604 | 0.017 | rs3129848(T) & rs2858867(C) & rs1978029(T) | 0.017 | 1.000 | 1.00 |
YRI | HLA-DQB*0605 | 0.042 | rs419132(G) & rs2157051(G) & rs5021448(T) | 0.042 | 1.000 | 1.00 |
YRI | HLA-DRB*0101 | 0.017 | rs439844(G) & rs3135391(T) | 0.017 | 1.000 | 1.00 |
YRI | HLA-DRB*0102 | 0.033 | rs2187818(C) & rs14004(T) | 0.033 | 1.000 | 1.00 |
YRI | HLA-DRB*0301 | 0.092 | rs3129763(T) & rs9275229(T) & rs9277489(A) | 0.083 | 0.713 | 0.89 |
YRI | HLA-DRB*0302 | 0.092 | rs3129878(G) & rs4599680(G) & rs7764856(A) | 0.092 | 1.000 | 1.00 |
YRI | HLA-DRB*0403 | 0.008 | rs1800624(T) | 0.008 | 1.000 | 1.00 |
YRI | HLA-DRB*0701 | 0.125 | rs1800624(T) & rs3828846(C) & rs2647045(A) | 0.125 | 0.853 | 0.92 |
YRI | HLA-DRB*0804 | 0.075 | rs507778(A) & rs3129954(C) & rs1061172(G) | 0.083 | 0.892 | 1.00 |
YRI | HLA-DRB*0901 | 0.025 | rs2242656(A) & rs1061808(T) & rs2395185(A) | 0.025 | 1.000 | 1.00 |
YRI | HLA-DRB*1101 | 0.058 | rs2395150(T) & rs12191360(C) & rs4713559(T) | 0.058 | 1.000 | 1.00 |
YRI | HLA-DRB*1102 | 0.025 | rs2395153(C) & rs241424(G) & rs2072915(A) | 0.025 | 1.000 | 1.00 |
YRI | HLA-DRB*1104 | 0.075 | rs558702(A) & rs7744293(A) | 0.050 | 0.649 | 1.00 |
YRI | HLA-DRB*1201 | 0.017 | rs4248166(C) & rs6918223(C) | 0.017 | 1.000 | 1.00 |
YRI | HLA-DRB*1301 | 0.083 | rs3134942(G) & rs3763308(T) & rs7451962(C) | 0.100 | 0.818 | 1.00 |
YRI | HLA-DRB*1302 | 0.058 | rs2157339(A) & rs7756467(T) | 0.058 | 1.000 | 1.00 |
YRI | HLA-DRB*1303 | 0.075 | rs11756657(G) & rs2516049(C) & rs2856718(A) | 0.075 | 1.000 | 1.00 |
YRI | HLA-DRB*1327 | 0.008 | rs2894239(G) & rs9368757(A) | 0.017 | 0.496 | 1.00 |
YRI | HLA-DRB*1335 | 0.008 | rs2982277(C) | 0.008 | 1.000 | 1.00 |
YRI | HLA-DRB*1401 | 0.025 | rs1612904(A) & rs2856717(T) | 0.025 | 1.000 | 1.00 |
YRI | HLA-DRB*1501 | 0.008 | rs443623(A) | 0.008 | 1.000 | 1.00 |
YRI | HLA-DRB*1503 | 0.092 | rs12191360(C) & rs4599680(A) | 0.100 | 0.908 | 1.00 |
CHB | HLA-A*0101 | 0.022 | rs1264709(T) | 0.022 | 1.000 | 1.00 |
CHB | HLA-A*0201 | 0.233 | rs892666(C) & rs4959037(A) & rs4678(C) | 0.244 | 0.941 | 1.00 |
CHB | HLA-A*0203 | 0.033 | rs2844713(A) & rs2269706(T) | 0.033 | 1.000 | 1.00 |
CHB | HLA-A*0206 | 0.056 | rs6457109(G) & rs9260988(A) | 0.056 | 1.000 | 1.00 |
CHB | HLA-A*0301 | 0.022 | rs3130785(G) | 0.022 | 1.000 | 1.00 |
CHB | HLA-A*0302 | 0.022 | rs1736924(G) & rs1557608(T) | 0.022 | 1.000 | 1.00 |
CHB | HLA-A*1101 | 0.233 | rs2517754(C) & rs7745235(A) | 0.233 | 1.000 | 1.00 |
CHB | HLA-A*2402 | 0.156 | rs2734984(A) & rs1611589(A) | 0.156 | 1.000 | 1.00 |
CHB | HLA-A*2601 | 0.011 | rs3823339(G) | 0.011 | 1.000 | 1.00 |
CHB | HLA-A*3001 | 0.056 | rs3218822(A) | 0.056 | 1.000 | 1.00 |
CHB | HLA-A*3101 | 0.033 | rs3823318(C) & rs1061235(A) | 0.033 | 1.000 | 1.00 |
CHB | HLA-A*3201 | 0.022 | rs9468692(C) | 0.022 | 1.000 | 1.00 |
CHB | HLA-A*3303 | 0.078 | rs2524005(A) & rs2855591(A) | 0.078 | 1.000 | 1.00 |
CHB | HLA-A*6801 | 0.022 | rs2844800(T) | 0.022 | 1.000 | 1.00 |
CHB | HLA-B*0705 | 0.011 | rs2523480(C) | 0.011 | 1.000 | 1.00 |
CHB | HLA-B*0801 | 0.022 | rs4248151(C) & rs3128982(C) | 0.022 | 1.000 | 1.00 |
CHB | HLA-B*1301 | 0.033 | rs707913(G) & rs2844586(A) | 0.033 | 1.000 | 1.00 |
CHB | HLA-B*1302 | 0.056 | rs7761138(G) & rs12212594(C) | 0.056 | 1.000 | 1.00 |
CHB | HLA-B*1501 | 0.089 | rs2524178(G) & rs3819294(A) | 0.100 | 0.878 | 1.00 |
CHB | HLA-B*1502 | 0.011 | rs3909184(C) & rs2844682(T) | 0.011 | 1.000 | 1.00 |
CHB | HLA-B*1511 | 0.011 | rs2074491(T) | 0.011 | 1.000 | 1.00 |
CHB | HLA-B*1518 | 0.033 | rs4084091(A) & rs3819294(A) | 0.033 | 1.000 | 1.00 |
CHB | HLA-B*3501 | 0.022 | rs1264307(A) & rs3128982(C) | 0.022 | 1.000 | 1.00 |
CHB | HLA-B*3503 | 0.022 | rs3130785(G) | 0.022 | 1.000 | 1.00 |
CHB | HLA-B*3701 | 0.011 | rs4947332(G) | 0.011 | 1.000 | 1.00 |
CHB | HLA-B*3801 | 0.011 | rs9295863(G) | 0.011 | 1.000 | 1.00 |
CHB | HLA-B*3802 | 0.033 | rs2844725(A) & rs3828875(T) | 0.033 | 1.000 | 1.00 |
CHB | HLA-B*3901 | 0.011 | rs1811197(T) & rs2844575(C) | 0.011 | 1.000 | 1.00 |
CHB | HLA-B*4001 | 0.122 | rs2844580(G) & rs2523694(C) | 0.111 | 0.898 | 1.00 |
CHB | HLA-B*4002 | 0.011 | rs6930444(G) & rs3130655(T) | 0.011 | 1.000 | 1.00 |
CHB | HLA-B*4006 | 0.044 | rs3819299(C) & rs8283(T) | 0.044 | 1.000 | 1.00 |
CHB | HLA-B*4601 | 0.111 | rs2243868(G) & rs2524227(A) & rs2857595(A) | 0.100 | 0.889 | 1.00 |
CHB | HLA-B*4801 | 0.044 | rs4959069(C) | 0.044 | 1.000 | 1.00 |
CHB | HLA-B*5101 | 0.078 | rs3905495(A) & rs7450800(C) & rs2471980(G) | 0.067 | 0.847 | 1.00 |
CHB | HLA-B*5201 | 0.044 | rs1062470(G) & rs2844586(A) | 0.044 | 1.000 | 1.00 |
CHB | HLA-B*5401 | 0.056 | rs3130786(A) & rs3819284(A) | 0.056 | 1.000 | 1.00 |
CHB | HLA-B*5601 | 0.011 | rs3130977(G) & rs1063632(T) | 0.011 | 1.000 | 1.00 |
CHB | HLA-B*5701 | 0.011 | rs3093726(T) | 0.011 | 1.000 | 1.00 |
CHB | HLA-B*5801 | 0.044 | rs3134792(G) & rs4713518(A) | 0.044 | 1.000 | 1.00 |
CHB | HLA-B*5901 | 0.011 | rs3094188(C) & rs1063632(T) | 0.011 | 1.000 | 1.00 |
CHB | HLA-B*6701 | 0.022 | rs2239523(G) & rs4947248(C) | 0.022 | 1.000 | 1.00 |
CHB | HLA-B*8101 | 0.011 | rs2507997(C) & rs3134954(C) | 0.011 | 1.000 | 1.00 |
CHB | HLA-C*0102 | 0.178 | rs3834326(A) & rs4122190(A) | 0.178 | 1.000 | 1.00 |
CHB | HLA-C*0302 | 0.044 | rs1265155(G) & rs4713438(T) | 0.044 | 1.000 | 1.00 |
CHB | HLA-C*0303 | 0.078 | rs6457350(C) & rs2156875(T) | 0.078 | 1.000 | 1.00 |
CHB | HLA-C*0304 | 0.044 | rs6457350(C) & rs4947248(C) | 0.044 | 1.000 | 1.00 |
CHB | HLA-C*0401 | 0.044 | rs7451258(C) & rs12662501(A) | 0.044 | 1.000 | 1.00 |
CHB | HLA-C*0602 | 0.078 | rs3130457(A) | 0.078 | 1.000 | 1.00 |
CHB | HLA-C*0702 | 0.200 | rs2001181(A) | 0.200 | 1.000 | 1.00 |
CHB | HLA-C*0704 | 0.011 | rs2395031(G) | 0.011 | 1.000 | 1.00 |
CHB | HLA-C*0801 | 0.144 | rs2524100(A) | 0.144 | 1.000 | 1.00 |
CHB | HLA-C*1202 | 0.044 | rs3094663(C) & rs2073723(T) | 0.044 | 1.000 | 1.00 |
CHB | HLA-C*1203 | 0.033 | rs6929434(T) | 0.033 | 1.000 | 1.00 |
CHB | HLA-C*1402 | 0.044 | rs3095301(T) & rs2073716(C) | 0.044 | 1.000 | 1.00 |
CHB | HLA-C*1502 | 0.056 | rs7451258(C) | 0.056 | 1.000 | 1.00 |
CHB | HLA-DQA*0101 | 0.100 | rs8365(C) & rs482044(C) & rs532098(C) | 0.089 | 0.878 | 1.00 |
CHB | HLA-DQA*0102 | 0.122 | rs5875382(G) & rs1063355(A) | 0.122 | 0.629 | 0.79 |
CHB | HLA-DQA*0103 | 0.144 | rs7744001(A) & rs1063355(A) & rs2187686(C) | 0.133 | 0.911 | 1.00 |
CHB | HLA-DQA*0201 | 0.067 | rs7763805(C) & rs3844313(A) | 0.056 | 0.824 | 1.00 |
CHB | HLA-DQA*0301 | 0.322 | rs2395533(T) & rs6903433(G) | 0.300 | 0.901 | 1.00 |
CHB | HLA-DQA*0401 | 0.022 | rs1694112(A) & rs4711312(C) | 0.022 | 1.000 | 1.00 |
CHB | HLA-DQA*0501 | 0.122 | rs4639334(C) & rs6908943(G) | 0.122 | 1.000 | 1.00 |
CHB | HLA-DQA*0601 | 0.078 | rs1061172(G) & rs3129718(A) | 0.078 | 1.000 | 1.00 |
CHB | HLA-DQB*0201 | 0.111 | rs4988889(G) | 0.111 | 1.000 | 1.00 |
CHB | HLA-DQB*0301 | 0.167 | rs6928482(G) & rs1056315(A) | 0.167 | 1.000 | 1.00 |
CHB | HLA-DQB*0302 | 0.067 | rs6906021(T) & rs9275184(G) | 0.067 | 1.000 | 1.00 |
CHB | HLA-DQB*0303 | 0.189 | rs2395533(T) & rs2856683(T) | 0.189 | 1.000 | 1.00 |
CHB | HLA-DQB*0401 | 0.067 | rs2077580(C) & rs2395533(T) & rs2300825(A) | 0.067 | 1.000 | 1.00 |
CHB | HLA-DQB*0402 | 0.033 | rs2076528(A) & rs1694112(A) & rs6937034(A) | 0.033 | 1.000 | 1.00 |
CHB | HLA-DQB*0501 | 0.011 | rs4947332(G) | 0.011 | 1.000 | 1.00 |
CHB | HLA-DQB*0502 | 0.078 | rs7744001(G) & rs6906021(C) & rs2300825(G) | 0.078 | 1.000 | 1.00 |
CHB | HLA-DQB*0503 | 0.044 | rs1794265(C) & rs241446(C) | 0.044 | 1.000 | 1.00 |
CHB | HLA-DQB*0601 | 0.144 | rs7744001(A) & rs6928482(A) | 0.144 | 1.000 | 1.00 |
CHB | HLA-DQB*0602 | 0.044 | rs3134975(T) & rs2621426(C) | 0.044 | 1.000 | 1.00 |
CHB | HLA-DQB*0603 | 0.011 | rs3806155(T) | 0.011 | 1.000 | 1.00 |
CHB | HLA-DQB*0604 | 0.033 | rs11758998(C) | 0.033 | 1.000 | 1.00 |
CHB | HLA-DRB*0301 | 0.067 | rs5000803(A) & rs7769979(T) & rs3129299(G) | 0.078 | 0.847 | 1.00 |
CHB | HLA-DRB*0401 | 0.022 | rs2239705(T) & rs2395175(T) | 0.022 | 1.000 | 1.00 |
CHB | HLA-DRB*0403 | 0.033 | rs2075800(T) & rs2395175(T) | 0.033 | 1.000 | 1.00 |
CHB | HLA-DRB*0404 | 0.011 | rs9404991(A) | 0.011 | 1.000 | 1.00 |
CHB | HLA-DRB*0405 | 0.078 | rs3129878(G) & rs2516049(C) | 0.078 | 1.000 | 1.00 |
CHB | HLA-DRB*0410 | 0.011 | rs4713521(T) & rs3130267(C) | 0.011 | 1.000 | 1.00 |
CHB | HLA-DRB*0701 | 0.067 | rs3129859(G) & rs2395177(C) | 0.056 | 0.824 | 1.00 |
CHB | HLA-DRB*0801 | 0.022 | rs4713479(A) & rs2763982(G) | 0.022 | 1.000 | 1.00 |
CHB | HLA-DRB*0802 | 0.022 | rs11757862(A) & rs1044506(C) | 0.022 | 1.000 | 1.00 |
CHB | HLA-DRB*0803 | 0.089 | rs3129859(C) & rs1041885(T) & rs154984(C) | 0.100 | 0.878 | 1.00 |
CHB | HLA-DRB*0901 | 0.178 | rs2395185(A) & rs2516049(T) | 0.178 | 1.000 | 1.00 |
CHB | HLA-DRB*1001 | 0.011 | rs4947332(G) | 0.011 | 1.000 | 1.00 |
CHB | HLA-DRB*1101 | 0.033 | rs4639334(T) & rs1383261(G) | 0.033 | 1.000 | 1.00 |
CHB | HLA-DRB*1201 | 0.056 | rs2105903(T) & rs2856718(A) & rs206777(C) | 0.056 | 1.000 | 1.00 |
CHB | HLA-DRB*1202 | 0.078 | rs6916742(A) & rs646984(G) & rs4947342(C) | 0.078 | 1.000 | 1.00 |
CHB | HLA-DRB*1301 | 0.011 | rs3873444(C) | 0.011 | 1.000 | 1.00 |
CHB | HLA-DRB*1302 | 0.033 | rs11758998(C) | 0.033 | 1.000 | 1.00 |
CHB | HLA-DRB*1401 | 0.044 | rs1799964(A) & rs3129961(G) & rs9469185(A) | 0.044 | 1.000 | 1.00 |
CHB | HLA-DRB*1407 | 0.011 | rs4248157(C) | 0.011 | 1.000 | 1.00 |
CHB | HLA-DRB*1444 | 0.011 | rs429853(G) & rs3129949(T) | 0.011 | 1.000 | 1.00 |
CHB | HLA-DRB*1501 | 0.067 | rs7773756(T) & rs6903608(G) & rs620202(C) | 0.067 | 1.000 | 1.00 |
CHB | HLA-DRB*1502 | 0.022 | rs2858880(A) | 0.022 | 1.000 | 1.00 |
CHB | HLA-DRB*1602 | 0.022 | rs7769073(T) & rs2227139(A) | 0.022 | 1.000 | 1.00 |
There are other HLA genes that have no significance or functional variants, but may be useful markers, such as: DR pseudogenes B7-B9.
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