Inclusion body myopathy 2
At a minimum, these SNPs are known to be related, and others may also be
Type 2 hereditary inclusion body myopathies (HIBM; IBM2) are autosomal recessive muscle wasting disorders, uncommon in the general world population but more common among people of Iranian Jewish descent.
IBM2 causes progressive muscle weakness and wasting. Muscle wasting usually starts around the age of 20 – 30 years. It can progress to marked disability within 10 – 15 years, confining many patients to a wheelchair. The weakness and severity, as well as the age of onset, varies significantly from person to person.