MEIS1
From SNPedia
| is a | gene |
| is | mentioned by |
| Full name | Meis homeobox 1 |
| EntrezGene | 4211 |
| PheGenI | 4211 |
| VariationViewer | 4211 |
| ClinVar | MEIS1 |
| GeneCards | MEIS1 |
| dbSNP | 4211 |
| Diseases | MEIS1 |
| SADR | 4211 |
| HugeNav | 4211 |
| wikipedia | MEIS1 |
| MEIS1 | |
| gopubmed | MEIS1 |
| EVS | MEIS1 |
| HEFalMp | MEIS1 |
| MyGene2 | MEIS1 |
| 23andMe | MEIS1 |
| UniProt | O00470 |
| Ensembl | ENSG00000143995 |
| OMIM | 601739 |
| # SNPs | 10 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs10865355 | 0 | 66,537,865 | |
| rs11678354 | 0 | 66,532,947 | |
| rs11897119 | 0 | 66,544,868 | |
| rs12469063 | 2 | 66,537,176 | |
| rs2192954 | 0 | 66,550,389 | |
| rs2300478 | 2 | 66,554,321 | |
| rs3891585 | 0 | 66,529,844 | |
| rs4544423 | 0 | 66,522,885 | |
| rs6710341 | 2 | 66,531,290 | |
| rs9789535 | 0 | 66,538,446 |
The MEIS1 gene is most likely important in development, but its functions remain unclear. Several SNPs in the MEIS1 gene, and in particular one haplotype, have been associated with increased risk for restless legs syndrome. [PMID 17637780]
These SNPs and haplotype are:
The association from this region that gives the highest association to restless legs syndrome is the haplotype consisting of the rs6710341(A) and rs12469063(G) alleles. This haplotype gives rise to an odds ratio of 2.75 (CI: 2.23-3.41). [PMID 17637780]
