Magnitude

Magnitude is a subjective measure of interest varying from 0 to 10. Over time it should be adjusted up or down by the community. It is generally interpreted as follows...

Magnitude	Description
0	You have the common genotype, for which nothing interesting is known.
0.1	You have the common genotype, but its interesting that this varies for others
1	Semi-plausible but not very exciting
(blank)	No one has yet assigned a magnitude. Treated as a 1.
2	looks interesting enough to be worth reading
2.1	hmm, interesting
3	Probably worth your time
4	Male/Female sex calls, used for QC, anything above this is definitely something you should pay attention to
10	Really significant information!

Numbers bigger than 10 are allowed and expected in the future. Since User:Watson and User:Steven Pinker requested not to learn their APOE4 gs216 status that serves as useful a landmark in the scale. Several rare genotypes are higher magnitude. The genotypes with highest magnitude are

	Magnitude	Repute	Summary
rs1801253(G;G)	0	Good
rs1801253(C;C)	1.1		responds well to bucindolol; may also depend on rs1801252
rs17822931(C;C)	2		Wet earwax. Normal body odour. Normal colostrum.
rs17822931(T;T)	2.5	Good	Dry earwax. No body odour. Likely Asian ancestry. Reduced colostrum.
rs16891982(C;C)	1.1	Good	generally non-European, but if European, 7x more likely to have black hair
rs16891982(G;G)	1.1		Generally European; Light skin; Possibly an increased risk of melanoma
rs1426654(A;A)	2.7		probably light-skinned, European ancestry
rs1426654(G;G)	2.6		probably darker-skinned, Asian or African ancestry
rs351855(C;C)	0	Good	normal
rs351855(T;T)	2.9	Bad	2x increased prostate cancer risk; among breast cancer patients, herceptin is less effective
... further results

The genosets with the highest magnitude are

	Magnitude	Repute	Summary
Gs318	10	Bad	Unsupported platform
Gs149	10		Testing for orientation issues
Gs303	7		WeGene quality control issues.
Gs300	7		Data Quality issue. Your data provider is reporting heterozygosity on the Y chromosome.
Gs306	6.5	Bad	Poor metabolizer of fluoropyrimidines (e.g. 5-fluorouracil, capecitabine or tegafur).
Gs267	6		APOE1/APOE1
Gs314	6	Bad	MUTYH-associated polyposis (and colon cancer risk)
Gs216	6	Bad	2 copies of the APOE-ε4 allele
Gs228	6	Bad	Sickle cell affected
Gs329	5.5	Bad	~6x higher risk for end-stage renal disease
... further results