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Max Magnitude

From SNPedia

SNPs can have multiple genotypes and each genotype can have it's own Magnitude, but Max Magnitude is a property of the SNP.

Imagine:

SNP rs1234

has 2 alleles C and T

So there are 3 genotypes, (C;C), (C;T) and (T;T)

(C;C) is the normal with Magnitude = 0

(C;T) is the heterozygote with Magnitude = 2.5

(T;T) is has Magnitude = 3.8

In a Promethease report, all 3 genotypes will have different Magnitudes, but they all have the same Max Magnitude (3.8), because that is the highest magnitude for any genotype of this SNP.

This gives us a single place to look to distinguish more interesting SNPs from less interesting ones.

 Max MagnitudeSummary
rs18012531.1
rs3320.5
rs1219090010
rs122553722.2Associated with slight increase in risks for T2D, breast and prostate cancers.
rs79031463.5Associated with T2D.
rs16952.1influences asthma risk
rs48781040
rs48773650
rs30874560
rs23027620
... further results