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Migraines

From SNPedia

Migrane is a type of headache. Understanding of genetics of migraine is proceeding fast, based on GWAS studies and large scale exome-sequencing studies. Among the main logi are TRPM8, PRDM16, and LRP1. This increase of knowledge is opening the door to personalized medicine and better medication as well.


[PMID 29932027] Circulating Biomarkers In Migraine. New Opportunities For Precision Medicine.

[PMID 29478595] Genetics of migraine.

[PMID 27681292OA-icon.png] Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.

[PMID 27322543OA-icon.png] Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.

[PMID 27543003OA-icon.png] Migraine genetics: from genome-wide association studies to translational insights.

Associated SNPs[edit]

These SNPs have been reported to potentially present increased risk for migraines:

These SNPs may also relate to migraines:

Numerous single studies indicate a correlation between a given SNP and migraines, but subsequent studies, whether of different populations, larger patient numbers, or via pooled meta-analyses, have often failed to replicate the initial findings. Caveat emptor!

Migrane medication[edit]

Drugs used to treat migraines may also be more or less successful based on a patient's genotype, since SNPs in a variety of genes affect the metabolism of these drugs. Some of the classes of drugs that have been used to treat migraines include the following:

See also[edit]

http://en.wikipedia.org/wiki/Migraine