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Nitrofurantoin

From SNPedia

Nitrofurantoin, sold under the trade name Macrobid and Furadantin among others, is an antibiotic used to treat bladder infections; however, it is not effective for kidney infections.Wikipedia

The FDA-approved label for Furadantin includes a warning that cases of hemolytic anemia of the primaquine-sensitivity type have been induced by nitrofurantoin, presumably due to G6PD-deficiencies as have been linked to primaquine. Hemolysis is an indication for discontinuing Furadantin.

PGx Table for Nitrofurantoin (Furadantin)
Genotype/Genoset Diplotype Gene Drug Use/Category/Class Medical Field Summary Descriptive Sentence
gs309 WT/WT G6PD Anti-bacterial Infectious Disease Normal Response Expected You do not appear to carry any G6PD mutations linked to an unwanted side effect (hemolytic anemia).
gs307 Carrier G6PD Anti-bacterial Infectious Disease Use with Caution You carry a G6PD mutation that might lead to an unwanted side effect (hemolytic anemia) when taking nitrofurantoin; be aware of FDA precaution.
gs308 G6PD-deficient G6PD Anti-bacterial Infectious Disease Use with Caution You carry a G6PD mutation linked to an unwanted side effect (hemolytic anemia) when taking nitrofurantoin; use with caution and monitor for hemolysis.