Nitrofurantoin
From SNPedia
Nitrofurantoin, sold under the trade name Macrobid and Furadantin among others, is an antibiotic used to treat bladder infections; however, it is not effective for kidney infections.Wikipedia
The FDA-approved label for Furadantin includes a warning that cases of hemolytic anemia of the primaquine-sensitivity type have been induced by nitrofurantoin, presumably due to G6PD-deficiencies as have been linked to primaquine. Hemolysis is an indication for discontinuing Furadantin.
| Genotype/Genoset | Diplotype | Gene | Drug Use/Category/Class | Medical Field | Summary | Descriptive Sentence |
|---|---|---|---|---|---|---|
| gs309 | WT/WT | G6PD | Anti-bacterial | Infectious Disease | Normal Response Expected | You do not appear to carry any G6PD mutations linked to an unwanted side effect (hemolytic anemia). |
| gs307 | Carrier | G6PD | Anti-bacterial | Infectious Disease | Use with Caution | You carry a G6PD mutation that might lead to an unwanted side effect (hemolytic anemia) when taking nitrofurantoin; be aware of FDA precaution. |
| gs308 | G6PD-deficient | G6PD | Anti-bacterial | Infectious Disease | Use with Caution | You carry a G6PD mutation linked to an unwanted side effect (hemolytic anemia) when taking nitrofurantoin; use with caution and monitor for hemolysis. |
