Osteoarthritis

Osteoarthritis, characterized by degeneration of articular cartilage, is the most common form of arthritis and a major concern for aging societies worldwide. Wikipedia

Heritability of severe osteoarthritis is approximately 30%, according to this 2003 report [PMID 12855031].

SNPs in various genes appear to be associated with osteoarthritis:

• DVWA
  • rs7639618
  • rs9864422
  • rs11718863

• FRZB
  • rs7775

• GDF5
  • rs143383 (risk allele T) [PMID 19479880]

• IL1RN
  • rs9005
  • rs315952
  • rs419598

• MCF2L
  • rs11842874 (risk allele G) 10.1016/j.ajhg.2011.08.001

[PMID 17195216] osteoarthritis - Sex and ethnic differences related to snps

[PMID 17704066] Multi-SNP model for estimating risk of osteoarthritis in both men and women

OMIM	607145
Desc	DYSTROBREVIN-BINDING PROTEIN 1; DTNBP1
Variant
Related	also