PRSS1
From SNPedia
| is a | gene |
| is | mentioned by |
| ClinVar | PRSS1 |
| GeneCards | PRSS1 |
| Diseases | PRSS1 |
| wikipedia | PRSS1 |
| PRSS1 | |
| gopubmed | PRSS1 |
| EVS | PRSS1 |
| HEFalMp | PRSS1 |
| MyGene2 | PRSS1 |
| 23andMe | PRSS1 |
| # SNPs | 23 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| i5005348 | |||
| i5005351 | |||
| i5005352 | |||
| rs10273639 | 0 | 142,749,077 | |
| rs111033564 | 0 | 142,751,808 | |
| rs111033565 | 4.4 | 142,751,938 | |
| rs111033566 | 2 | 142,750,600 | |
| rs111033567 | 4.4 | 142,750,582 | |
| rs111033568 | 4.4 | 142,751,937 | |
| rs144422014 | 2 | 142,750,675 | |
| rs193922655 | 0 | 142,751,962 | |
| rs193922656 | 0 | 142,751,971 | |
| rs199769221 | 0 | 142,751,920 | |
| rs202003805 | 4.4 | 142,750,561 | |
| rs267606982 | 0 | 142,751,938 | |
| rs28934902 | 0 | 142,751,808 | |
| rs387906698 | 4.4 | 142,751,919 | |
| rs397507439 | 4.4 | 142,750,630 | |
| rs397507440 | 4.4 | 142,751,988 | |
| rs397507441 | 4.4 | 142,750,585 | |
| rs397507442 | 4.4 | 142,750,579 | |
| rs606231345 | 0 | 142,751,920 | |
| rs77914057 | 0 | 142,751,938 |
The PRSS1 gene on chromosome 7 encodes "protease, serine 1", also known as cationic trypsinogen. Cationic trypsinogen is produced in the pancreas and helps with the digestion of food.GHR
Mutations in the PRSS1 gene have primarly been linked to a dominantly inherited form of hereditary pancreatitis. More than 40 mutations in the PRSS1 gene are considered pathogenic for this condition; the most common in early-onset (pediatric) acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP) has been reported to be R122H (rs111033565).10.1016/j.jpeds.2017.03.063
